188株血液培养阳性病人病原菌分布及耐药分析

Analysis of pathogens distribution and antibiotic resistance of 188 positive pathogens isolated from blood culture

目的研究2016年上半年入该院血液培养阳性病人病原菌分布和耐药情况,为临床用药提供科学依据。方法收集2016年1月1日—2016年6月30日入院病人血培养,阳性者进行细菌培养和鉴定,用Whonet5.6软件耐药情况分析。结果2016上半年总共有1 760例病人做血液培养,188例培养阳性,阳性率是10.68%,革兰阴性杆菌102株,占54.26%,大肠埃希菌(57株)、鲍曼不动杆菌(8株)和铜绿假单胞菌(8株);革兰阳性球菌74株,占39.36%,表皮葡萄球菌(23株)、金黄色葡萄球菌(20株)和粪肠球菌(12株);真菌12株,占6.38%。大肠埃希菌对美平和亚胺培南耐药率为0。表皮葡萄球菌、金黄色葡萄球菌对糖肽类抗生素(万古霉素、替考拉宁和利奈唑胺)的耐药率均为0,未发现耐万古霉素的葡萄球菌。结论 2016上半年该院血培养阳性最多的菌株是大肠埃希菌,对血培养阳性结果进行细菌培养和药敏鉴定,为临床诊断治疗用药提供科学依据。

Objective To analyze the pathogenic bacteria distribution and drug resistance of 188 positive pathogens from blood culture in our hospital in the first half of 2016,and provide scientific basis for clinical therapy. Methods Blood cultures were collected from January to June in 2016, and pathogens were identified and susceptibility was detected. The data was analyzed by software Whonet5. 6. Results Among 1 760 blood culture, there were 188 positive, accounting for 10.68%. The Gram-negative were 102, accounting for 54.26%. E. coli were 57 strains, Acinetobacter baumannil were 8 strains and P. aeruginosa were 8 strains. The Gram-positive were 74 strains, Staphylococcus epidermidis were 23 strains, Staphylococcus aureus were 20 strains, Enterococcus faecalis were 12 strains. Fun-gus were 12 strains,the rate was 6. 38%. None E. Coli were found resistant to Mepem and Imipenem. Glycopeptides resistance of the first two positive pathogens was 0. There was no vancomycin-resistant Staphylococcus. Conclusion E. coli accounted the most in blood cultrue. By analysis the variety of pathogens and drug resistance, we provide evidence for scientific use of clinical medicine.