桥本甲状腺炎患者血脂、血糖和血清胱抑素C水平的临床意义

Clinical significance of blood lipid,blood glucose and serum cystatin C levels in patients with Hashimoto thyroiditis

目的:探讨桥本甲状腺炎患者血脂、血糖和血清胱抑素C水平变化和临床意义。方法:选取47例甲状腺功能正常的桥本甲状腺炎患者作为研究A组;42例桥本氏亚临床甲减的患者作为研究B组;77例健康体检者作为对照组。测定并比较3组研究对象的促甲状腺激素(TSH)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血糖(GLU)以及血清胱抑素C(CYS-C)水平。结果:研究A组患者的TG、LDL-C水平低于对照组,差异有统计学意义(P<0.05),而CYS-C水平明显高于对照组,差异有统计学意义(P<0.05);研究B组患者的TC、LDL-C水平高于对照组,差异有统计学意义(P<0.05),而GLU、CYS-C水平低于对照组,差异有统计学意义(P<0.05)。根据研究A组、B组的数据分析,TSH与TC、LDL-C呈正相关(r=0.519、0.582,P<0.05)、与CYS-C呈负相关(r=-0.83,P<0.01)。结论:桥本甲状腺炎患者可引起其血脂、血糖和血清胱抑素C水平的变化,可作为本病诊断及预后的参考。

Objective： To explore changes and clinical significance of blood glucose,blood lipid and serum cystatin C levels in patients with Hashimoto thyroiditis. Methods ： 47 patients with Hashimoto＇s thyroiditis and normal thyroid function were chosen as ex-perimental group A,42 cases with Hashimoto subclinical hypothyroidism were used as experimental group B,and 77 healthy persons were selected as control group. The levels of thyroid stimulating hormone （ TSH） , total cholesterol （ TC ） , triglyceride （ TG ） , high density lipoprotein cholesterol （HDL-C）,low density lipoprotein cholesterol （LDL-C）,glucose （Glu） and serum cystatin C （Cys- C） of the three groups were detected and compared. Results ： The TG and LDL-C levels of the experimental group A were lower than those of the control group,and the differences were statistically significant （P〈0.05） ; while the Cys-C level was significantly higher than that of the control group,and the difference was statistically significant （P〈0. 05 ）. The TC and LDL-C levels of the experimental group B were higher than those of the control group,and the differences were statistically significant （P〈0.05） ; while the Glu and Cys -C levels were significantly lower than those of the control group,and the differences were statistically significant （P〈0. 05） According to the experimental data of A and B group, there were positive correlations among TSH and T C, LD L -C （ r = 0. 5 1 9,0 .5 8 2,P 〈 0.05）,and there was a negative correlation between TSH and CYS-C （ r= -0. 83,P 〈 0 . 0 1 ） . Conclusions ： Hashimoto thyroiditis can cause the changes of blood lipid,blood glucose and serum cystatin C levels,which can be used as a reference for the clinical diagnosis and prognosis of the disease.