新疆哈萨克族超重2型糖尿病患者血脂、血尿酸与胰岛素抵抗的关系

Relationships between blood lipid and blood uric acid with insulin resistance in overweight patients with T2DM in Kazak nationality in Xinjiang

目的:分析新疆哈萨克族超重2型糖尿病(T2DM)患者血脂、血尿酸与胰岛素抵抗(IR)的关系。方法:选取245例T2DM患者,其中哈萨克族121例(超重组63例、非超重组58例),汉族124例(超重组65例、非超重组59例),另选同期体检正常者129例为对照组,其中哈萨克族65例,汉族64例。比较各组一般资料以及两民族T2DM患者使用降糖药情况,分析两民族T2DM患者稳态模型胰岛素抵抗指数(HOMA-IR)与各指标的相关性。结果:两民族超重组TC、TG显著高于其对照组;哈萨克族超重组HDL-C水平与对照组比较无明显差异(P>0.05),而显著高于汉族超重组和汉族非超重组,LDL-C水平显著高于其对照组、低于汉族超重组;哈萨克族超重组血尿酸水平显著高于其余各组,且HOMA-IR明显大于其对照组和汉族各组(P<0.05或P<0.01)。两民族T2DM患者降糖药使用情况比较无显著差异(P>0.05)。相关性分析表明,两民族T2DM患者HOMA-IR均与血尿酸水平均呈明显正相关(P<0.05)。结论:哈萨克族超重T2DM患者IR和高尿酸血症更为突出,而汉族超重者HDL-C降低及LDL-C升高更为突出。

Objective To analyze the relationships between blood lipid and blood uric acid with insulin resistance （ IR） in overweightpatients with type 2 diabetes mellitus （ T2DM ） in Kazak nationality in Xinjiang. Methods： A total of 245 patients with T2DMwere selected,in whom 121 （63 were overweight and 58 were non - overweight） were Kazak nationality and 124 （65 were overweightand 59 were non - overweight） Han nationality. Another 129 healthy people taking physical examinations in corresponding periodserved as control group （65 were Kazak nationality and 64 were Han nationality）. General data were compared among groups and theapplication rate of antidiabetic drugs were compared between two nationalities, and the correlation between homeostasis model assessmentof insulin resistance （H O M A -IR） and each index were analyzed in patients with T2DM in the two nationalities. Results ： Totalcholesterol （ TC ） and triglyceride （T G ） were evidently higher in overweight groups of two nationalities than those in control group. Thehigh-density lipoproteincholesterol （H D L-C ） in overweight group of Kazak nationality had insignificant difference with control group（P 〉 0. 05） , but was evidently higher than overweight and non - overweight groups of Han nationality, and was prominently higher thancontrol group and notably lower than overweight group of Han nationality in low-density lipoproteincholesterol （L D L -C ）. Overweightgroup of Kazak nationality was prominently higher in blood uric acid level than the rest groups, and was significantly higher in HOMAIRthan control group and two groups of Han nationality （ P 〈 0. 05 or P 〈 0. 01） . There was no significant difference in the use of hypoglycemicdrugs in patients with T2DM between two nationalities （P 〉 0. 0 5 ）. Correlation analysis showed that HOMA-IR was in positiveassociation with blood uric acid level in patients with T2DM between two nationalities （P 〈 0. 0 5 ）. Conclusion：IR and hyperuricemiaare more prominent in overweight patients with T2DM in Kazak nationality, while HDL-C decrease and LDL-C increase are more prominentin Han nationality overweight.