中晚期肺癌患者D-二聚体水平的临床意义

Clinical Significance of D-dimer Level of Patients with Middle-late Stage Lung Cancer

目的探讨中晚期肺癌患者D-二聚体的临床意义。方法方便选取该院2013年1月—2015年1月手指的Ⅲ~Ⅳ期经病理确诊的60例中晚期肺癌患者,其中Ⅲ期38例,Ⅳ期22例;鳞癌22例,腺癌23例,小细胞癌15例,检测分析D-二聚体水平,D-二聚体浓度≥0.5 mg/L为阳性。结果肺癌患者Ⅲ期D-二聚体均值为(0.54±0.09)mg/L,Ⅳ期D-二聚体均值为(1.38±0.36)mg/L,差异有统计学意义(P<0.05),分期与患者D-二聚体水平呈正相关,分期越晚,D-二聚体水平越高。不同肿瘤病理类型之间D-二聚体有一定差异,腺癌D-二聚体均值为(0.73±0.41)mg/L,鳞癌D-二聚体均值为(2.11±0.71)mg/L,小细胞癌D二聚体均值为(1.45±0.23)mg/L,两两比较发现腺癌与小细胞肺癌,差异无统计学意义(P>0.05),鳞癌与腺癌、小细胞肺癌比较差异有统计学意义(P<0.05)。吸烟组D-二聚体均值为(2.37±0.74)mg/L,不吸烟组D二聚体均值为(1.15±0.23)mg/L,两者比较差异有统计学意义(P<0.05)。结论 D-二聚体对中晚期肺癌的分期及病理类型的有一定临床意义,晚期肺癌患者中是否吸烟对D-二聚体有重要影响。

Objective To study the clinical significance of D-dimer level of patients with middle-late stage lung cancer.Methods 60 cases of patients with middle-late stage lung cancer（ Ⅲ-Ⅳ stages） diagnosed by pathology in our hospital from January 2013 to January 2015 were conveniently selected, including 38 cases in Ⅲ stage, 22 cases in Ⅳ stage, 22 cases with squamous cell carcinoma, 23 cases with adenocarcinoma and 15 cases with small cell carcinoma, and the D-dimer level was tested and analyzed and the D-dimer concentration ≥0.5 mg/L was positive. Results The average value of D-dimer level of patients with lung cancer during the Ⅲ stage was（0.54±0.09）mg/L, and the average value of D-dimer level of patients with lung cancer during the Ⅳ stage was（1.38±0.36）mg/L, and the difference was statistically significant（P〈0.05）, and the staging was positively correlation with the D-dimer level of patients, the later the staging, the higher the Ddimer level, and there was a certain difference in the D-dimer level between different tumor pathological types, and the average values of squamous cell carcinoma, adenocarcinoma and small cell carcinoma were respectively（0.73 ±0.41）mg/L,（2.11±0.71）mg/L and（1.45±0.23）mg/L, and the comparison showed that there was no obvious difference between the adenocarcinoma and small cell carcinoma（P〉0.05）, and the difference between the squamous cell carcinoma, adenocarcinoma and small cell carcinoma was statistically significant, and the difference in the average value of D-dimer level between the smoking group and the non-smoking group was statistically significant[（2.37±0.74）mg/L vs（1.15±0.23）mg/L]（P〈0.05）. Conclusion The D-dimer is of a certain clinical significance to the staging and pathological type of middle-late stage lung cancer, and whether the patients with middle-late stage lung cancer smoke or not has an important effect on the D-dimer.