布地奈德雾化吸入联合小剂量红霉素治疗小儿喘息性支气管肺炎(ABP)的疗效刍议

Analysis of Budesonide Inhalation Aerosol and Small-dose Erythromycin in Treatment of Asthematoid Bronchopneumonia in Children

目的探讨布地奈德雾化吸入联合小剂量红霉素治疗小儿喘息性支气管肺炎(ABP)的疗效。方法方便选取88例患儿均为该院2013年1月—2016年10月期间收治的喘息性支气管肺炎病例,按照双色球分组法将其分为两组。单纯接受布地奈德雾化吸入治疗的44例患儿为对照组,实施布地奈德雾化吸入联合小剂量红霉素治疗的44例患儿为观察组,对比治疗状况。结果治疗7 d后,观察组患儿治疗总有效率93.18%显著优于对照组72.73%,差异有统计学意义(P<0.05)。治疗过程中,观察组不良反应6.82%与对照组11.36%比较差异无统计学意义(P>0.05),但观察组患儿咳嗽、气促、肺哮鸣音消失时间均显著低于对照组,差异有统计学意义(P<0.05)。观察组入院时肺功能FEV1、FEV/FVC与治疗后有显著改善,且优于对照组,差异有统计学意义(P<0.05)。结论布地奈德雾化吸入联合小剂量红霉素治疗小儿喘息性支气管肺炎的效果较好,症状得到改善,不良反应少,安全性高,可推广。

Objective To discuss the curative effect of budesonide inhalation aerosol and small-dose erythromycin in treatment of asthematoid bronchopneumonia in children. Methods 88 cases of children with asthematoid bronchopneumonia admitted and treated in our hospital from January 2013 to October 2016 were conveniently selected and randomly divided into two groups with 44 cases in each, the control group only adopted the budesonide inhalation aerosol, while the observation group adopted the budesonide inhalation aerosol and small-dose erythromycin, and the treatment situation was compared between the two groups. Results After 7 d treatment, the total treatment effective rate in the observation group was obviously better than that in the control group,（93.18% vs 72.73%）, and the difference was statistically significant（P〈0.05）, in the treatment course, the difference in the adverse reaction rate between the observation group and the control group was not statistically significant（6.82% vs 11.36%）（P〉0.05）, but the disappearance time of cough, breath pant and lung wheezing in the observation group was obviously lower than that in the control group, and the difference was statistically significant（P〈0.05）, and the lung function FEV1 and FEV/FVC obviously improved after treatment compared with those at admission, and the improvement was better than those in the control group, and the difference was statistically significant（P〈0.05）. Conclusion The effect of budesonide inhalation aerosol and small-dose erythromycin in treatment of asthematoid bronchopneumonia in children is better, and the symptoms are improved with few adverse reaction and high safety, which can be promoted.