多发性骨髓瘤患者凝血相关指标的临床研究

Clinical Research on Coagulation Related Indexes of Patients with Multiple Myeloma

目的探讨多发性骨髓瘤病患凝血相关指标在临床中的意义。方法方便择取2013年8月—2016年8月该院收治的30例MM患者作为病例组,同时选取体检中心的健康人30名作为对照组,比较两组ATⅢ、PT、APTT、TT、FIB、D-D及血小板最大聚集率差异情况。结果病例组PT[(12.10±2.45)s]、APTT[(30.47±15.93)s]、TT[(19.68±2.97)s]、FIB[(2.30±0.69)g/L]、D-D[(0.73±0.60)mg/L]、MAR[(56.60±16.78)%]指标水平显著高于对照组[PT(10.91±0.63)s、APTT(23.34±5.19)s、TT(15.61±1.13)s、FIB(1.98±0.25)g/L、D-D(0.24±0.11)mg/L、MAR(44.64±7.35)%],组间数据差异有统计学意义(P<0.05)。结论 MM疾病患者机体处于易栓状态,同时患者疾病分期越重,ATⅢ越低。

Objective To discuss the clinical significance of coagulation related indexes of patients with multiple myeloma in clinic. Methods 30 cases of MM patients admitted and treated in our department from August 2013 to August 2016 were conveniently selected as case group, while 30 cases of healthy people in the physical examination center were selected as the control group, and the differences in the ATⅢ,PT,APTT,TT,FIB,D-D and maximum platelet aggregation rate were compared between the two groups. Results The PT, APTT, TT, FIB, D-D and MAR in the case group were obviously higher than those in the control group[（12.10±2.45）s,（30.47±15.93）s,（19.68±2.97）s,（2.30±0.69）g/L,（0.73±0.60）mg/L,（56.60±16.78）% vs（10.91±0.63）s,（23.34±5.19）s,（15.61±1.13）s,（1.98±0.25）g/L,（0.24±0.11）mg/L,（44.64±7.35）%], and the differences between the two groups were statistically significant（P〈0.05）. Conclusion The organism of patients with MM diseases is at the thrombophilia state, at the same time, the more severe the disease staging, the lower the ATⅢ.