生长抑素治疗急性胰腺炎的临床效果分析

Analysis of Clinical Effect of Calcitonin Gene Related Peptides in Treatment of Acute Pancreatitis

目的探讨生长抑素治疗急性胰腺炎的临床有效性与安全性。方法随机选取2015年1月—2016年10月该院内科收治的94例急性胰腺炎患者为研究对象,依入院单双号将病例分为两组。对照组47例,患者行常规内科治疗;实验组47例,患者在对照组治疗基础上加用生长抑素。对比观察两组疗效及用药不良反应,统计两组症状缓解时间、血淀粉酶恢复时间、住院时间。结果实验组治疗显效率(59.57%)和治疗总有效率(95.75%)显著高于对照组患者症状缓解时间(2.3±0.4)d,AMS恢复时间(4.5±0.8)d,住院时间(6.8±0.5)d,各项指标均优于对照组(P<0.05)。两组用药期间仅个别患者见轻度不良反应,不影响治疗,组间不良反应发生率比较差异无统计学意义(P>0.05)。结论以生长抑素治疗急性胰腺炎能明显缩短病程、提高治疗效果、促进患者早期康复,用药安全有效,值得推广使用。

Objective To discuss the clinical effectiveness and safety of calcitonin gene related peptides in treatment of acute pancreatitis. Methods Random selection 94 cases of patients with acute pancreatitis admitted and treated in our hospital from January 2015 to October 2016 were selected as the research objects and divided into two groups according to the admission order with 47 cases in each, the control group adopted the routine medical treatment, while the experimental group added the calcitonin gene related peptides treatment on the basis of the control group, and the curative effect and medication adverse reactions of the two groups were observed and compared and the symptoms relief time, amy serum amylase recovery time and length of stay of the two groups were counted. Results The treatment markedly effective rate（59.57%） and total treatment effective rate（95.75%） in the experimental group were obviously higher than those in the control group（2.3±0.4）d, and the AMS recovery time and length of stay were respectively（4.5±0.8）d and（6.8±0.5）d, which were better than those in the control group（P〈0.05）. Conclusion The calcitonin gene related peptides in treatment of acute pancreatitis can obviously shorten the disease course, improve the treatment effect and promote the early recovery of patients and the medication is safe and effective, which is worth promotion and application,.