吸入布地奈德混悬液对毛细支气管炎后喘息的影响

Effect of Udesonide on Bronchial Asthma by Inhaling on the Wheezing of Capillary Bronchitis

目的探讨吸入布地奈德混悬液对毛细支气管炎后喘息的影响。方法方便收集2014年5月—2015年12月期间在该院儿科接受治疗的200例毛细支气管炎婴幼患儿,根据患儿入院序号,单号纳入观察组100例,双号纳入常规组100例。常规组采用常规治疗。观察组则在常规组基础上加用布地奈德混悬液雾化吸入治疗。观察两组患儿治疗前后血清白细胞介素-4(IL-4)、IL-8及肿瘤坏死因子-α(TNF-α)水平的变化及临床疗效,并记录患儿随访1年期间是否发生喘息及喘息次数。结果观察组的治愈率、总有效率(48.0%、97.0%)明显高于常规组(34.0%、89.0%)(P<0.05)。治疗后,观察组患儿血清IL-4、IL-8、TNF-α水平分别为(4.3±1.2)、(40.7±9.3)、(71.4±19.8)pg/mL,明显低于常规组的(5.3±1.3)、(46.3±9.4)、(81.2±21.6)pg/mL。观察组随访期间喘息发生率、平均年喘息次数分别为17.0%、(2.7±0.3)次明显低于常规组的37.0%和(3.5±0.4)次(P<0.05)。结论布地奈德混悬液雾化吸入治疗毛细支气管炎患儿喘息可提高临床疗效,降低药物使用量,减轻炎症细胞因子的释放,降低病后1年内的喘息率,且起效快、作用强,值得临床推广应用。

Objective To discuss the effect of udesonide on Bronchial Asthma by Inhaling on the Wheezing of capillary bronchitis. Methods Convenient selection 200 cases of children with capillary bronchitis treated in our hospital from May2014 to December 2015 were collected and divided into two groups with 100 cases in each according to the admission order, the routine group adopted the routine treatment, while the observation group added the Bronchial Asthma by Inhaling on the basis of the routine group, and the serum IL-4, IL-8 and TNF-α level changes and clinical curative effect of the two groups were observed and whether Wheezing occurred to children or not and wheezing frequency of children during one-year follow-up were recorded. Results The cure rate and total effective rate in the observation group were obviously higher than those in the routine group（48.0%, 97.0% vs 34.0%, 89.0%）（P〈0.05）, after treatment, the serum IL-4,IL-8,TNF-α levels in the observation group were obviously higher than those in the routine group[（4.3±1.2）,（40.7±9.3）,（71.4±19.8）pg/mL vs（5.3±1.3）,（46.3±9.4）,（81.2±21.6）pg/mL], and the incidence rate of wheezing during follow-up and average wheezing frequency in the observation group were obviously lower than those in the routine group[17.0%,（2.7±0.3） vs 37.0%,（3.5±0.4）]（P〈0.05）. Conclusion The inhalation treatment of bronchial asthma in treatment of wheezing of capillary bronchitis can improve the clinical curative effect, reduce the drug dosage, relieve the release of inflammatory cell factors and reduce the wheezing rate in 1 year after disease with quicker and stronger effect, which is worth clinical promotion and application.