肝爽片薄膜包衣工艺及稳定性研究

Film-coating Technology of Ganshuang Tablets and their Stability

目的研究肝爽片薄膜包衣的最佳工艺参数,提高肝爽片的稳定性。方法采用正交试验,以崩解时间及包衣合格率为指标,确定肝爽片薄膜包衣的最佳工艺参数。结果肝爽片薄膜包衣的最佳工艺参数:包衣增重率为3%、包衣液浓度为10%、片床温度为40℃。此参数下,薄膜包衣片的性状、崩解时限、芍药苷含量等指标在稳定性考察期内无显著变化;结论肝爽片薄膜包衣工艺简便高效,科学合理,稳定、可行。

Objective To optimize the parameters of film coating technology for Ganshuang tablets in order to improve their stability.Met partial qualified rate of coating wer technology technology of 10%,an holds Orthogonal test method was adopted.The e used as indicators, and the most suitable par disintegration time and ameters of film coating for Ganshuang tablets were confirmed. Results The most suitable parameters of film coating of Ganshuang tablets were：a coating weight gain rate of 3 %, a concentration d a tablet bed temperature of 40 ℃.The disintegration time of the film coating eter was significantly shortened.The property an change while their stability was studied.Conclusi simple and efficient, well-designed,stable and fe of coating solution d paeonifiorin content of these tablets did not significantly on This film coating technology for Ganshuang tablets is asible.