FOXQ1在甲状腺乳头状癌中的表达及意义

The Significance of FOXQ1 Expression in Papillary Thyroid Carcinoma

采用Real-time PCR、Western blot及免疫组化法检测甲状腺乳头状癌(papillary thyroid carcinoma,PTC)组织与正常甲状腺组织中叉头框Q1(forkhead box Q1,FOXQ1)m RNA及蛋白质水平,对比分析其与PTC临床病理特征间的关系,探讨FOXQ1在PTC发生发展中的作用。研究结果显示,PTC中FOXQ1 mRNA及蛋白质水平均高于正常甲状腺组织,其水平差异具有统计学意义(P<0.01);FOXQ1 mRNA及蛋白质水平与PTC患者淋巴结转移及TNM分期密切相关(P<0.05),而与性别、年龄、肿瘤大小及是否合并桥本氏甲状腺炎间差异无显著统计学意义(P>0.05)。FOXQ1在PTC中高表达及其和淋巴结转移、TNM分期的正相关提示该蛋白在PTC中可能具有促癌作用。

This study revealed the relationship between forkhead box protein Q1 （FOXQ1） expression levels and the clinicopathological feature in papillary thyroid carcinoma （PTC）. We investigated the role of FOXQ1 in PTC development using Real-time PCR, Western blot and immunohistochemistry to detect FOXQ1 mRNA and protein levels in PTC and normal thyroid tissue samples. The results showed that the FOXQ1 mRNA and protein levels in PTC group were higher than normal thyroid group （P〈0.01）. The high levels of FOXQ1 mRNA and protein were positively correlated to the status of lymphatic metastasis and the stage of TNM in PTC （P〈0.05）, but no significant relationship with gender, age, rumor size, concurrent Hashimoto＇s thyroiditis （HT） was identified （P〉0.05）. These results suggested that FOXQ1 might play an oncogenic role in PTC.