慢性精神分裂症住院患者血清叶酸、维生素B12及铁蛋白水平的研究

Levels of serum folate, vitamin B12 and ferritin in patients with schizophrenia

目的探讨精神分裂症患者的血清叶酸、维生素B12及铁蛋白水平分布特点。方法对10424例精神分裂患者进行血液采样，采用电化学发光技术检测血清叶酸、维生素B12、铁蛋白水平，并比较不同性别、年龄患者的水平差异。结果精神分裂症患者中，较低维生素B。叶酸及铁蛋白水平的发生率普遍〉5％，低叶酸水平发生率高达38．29％，低维生素B12的发生率为18．14％。精神分裂症患者的叶酸水平存在性别差异（t=-5．83，P〈0．01），维生素B12水平存在年龄差异（t=2．08，P〈0．05）。结论慢性精神分裂症患者低血清维生素B12、叶酸及铁蛋白水平的发生率高，需要予以积极关注。

Objective To investigate the distribution of serum folate, vitamin B12 and ferritin in patients with schizophrenia.Methods Blood samples were collected from 1042 patients with schizophrenia. Levels of serum folate, vitamin B12 and ferritin were detected by electrochemiluminescence immunoassay.Re-sultsThe prevalence of low vitamin B12, folate and ferritin levels in schizophrenia patients was generally higher than 5%. And the prevalence of low folate was as high as 38.29%. The prevalence of low vitamin B12 was about 18.14%. There were gender differences in levels of folate （t=-5.83,P〈0.01）, and age differences in levels of vitamin B12 （t=2.08,P〈00.05） in patients with schizophrenia.Conclusions The prevalence of low serum vita-min B12, folate and ferritin levels in patients with chronic schizophrenia is high, which need to be actively con-cerned about.