舌炎方治疗萎缩性舌炎气阴两虚证临床研究

Clinical Research on Atrophic Glossitis of Qi and Yin Deficiency Syndrome Treated with Glossitis Prescription

目的:观察舌炎气治疗萎缩性舌炎气阴两虚证的临床疗效,观察治疗前后患者体内血栓素B2(throm boxane,TXB2)和6-酮-前列腺素F1a(6-Keto-PGF1a)的水平变化。方法:将符合纳入标准的萎缩性舌炎患者60例,随机分为两组,对照组30例,使用叶酸、维生素B1各10 mg,日3次,口服;烟酰胺200 mg,日3次,口服;维生素B12,每次500 ug,隔日1次肌注。治疗组使用舌炎方,药品使用单味药免煎冲剂,按说明混合后用温开水冲服,日2次。两组患者均连续治疗1月。结果:治疗组30例,显效18例,有效11例,无效1例,有效率为96.43%,对照组30例,显效15例,有效8例,无效7例,有效率为76.67%,两组有效率比较,有显著性差异(P<0.05),治疗组疗效优于对照组;两组患者治疗后临床疗效、中医证候疗效、中医证候疗效评分以及血浆TXB2和6-Keto-PGF1a含量与治疗前比较均有显著性差异(P<0.05)。两组患者治疗后TXB2含量降低、6-Keto-PGF1a含量升高,组间比较有显著性差异(P<0.05)。结论:舌炎方治疗萎缩性舌炎气阴两虚证可明显改善患者口干、舌痛症状,促进舌乳头的生长,并可改善舌部微循环,促进上皮细胞功能恢复。

Objective： To obsela, e the clinical effects of Glossitis Prescription on atrophic glossitis of qi and yiu deficiency syndrome and the ehanges of the levels of TXB2 and 6-Keto-PGFla. Methods： Totally 60 patients with atrophic glossitis were randomized into control group and treatment group, 30 cases in each group. Control group were orally given Folic Acid of lOmg, Vitamin B1 of 10rag and Nieotinamide of 200rag three times a day, intramuscular injection of Vitamin B12 of 500ug every other clay. Treat- ment group were given Glossitis Prescription. The drug was composed of single herb electuary free from decoeting and taken after mixed with warm boiled water twice a day. Both groups were treated continuously for 1 month. Results： Among the 30 cases in treatment group, 18 cases were with excellent effects, 11 cases with effects, 1 case without effect; the effective rate was 96.43%. Among the 30 cases in control group, 15 cases were with excellent effects, 8 cases with effects, 7 case without effect; the effective rate was 76.67%. The difference of effective rate between two groups had statistical significance （ P 〈0.05 ） ; treat- ment group were superior to control group. There were significant differences in the clinical effects, TCM symptoms effeets, scores of TCM symptom effects and contents of plasma TXB2 and 6-Keto-PGFl a between two groups （P 〈 O. 05）. The content of TXB2 declined and content of 6-KeIo-PGFla inelased in both groups, and there was significant difference between the two groups （P 〈0.05）. Conclusion： In the treatment of atrophic glossitis of qi and yin deficiency syndrome, Glossitis Prescription can obviously improve the symptoms of dry mouth and tongue pain, promote the growth of lingual papilla, enhance the micro-cir- culation of the tongue, and accelerate the functional recovery of epithelial cells.