补肾强筋胶囊治疗围绝经期及绝经后期膝骨性关节炎临床研究

Clinical Research on Permenopausal and Postmenopausal Knee Osteoarthritis Treated with Kidney-Tonifying and Blood-Activating Prescription

目的:比较补肾强筋胶囊治疗围绝经期及绝经后期膝骨性关节炎的临床疗效。方法:选择2014年1月—2015年9月就诊于本院骨科门诊的围绝经期膝骨性关节炎76例为观察组A,绝经后期膝骨性关节炎95例为观察组B,两组患者均采用补肾强筋胶囊治疗,比较两组患者治疗前后关节活动范围、VAS评分的改善情况,以及不同证型的疗效情况。结果:两组患者治疗前后活动范围、各VAS评分比较,均有显著性差异(P<0.05);但两组之间比较,差异无统计学意义(P>0.05)。中医证候疗效结果显示,同组患者肝肾亏虚证、瘀血闭阻证之间比较,均无显著差异(P>0.05),两证型均显著优于风寒湿痹证(P<0.05)。结论:补肾强筋胶囊对围绝经期、绝经后期膝骨性关节炎肝肾亏虚证、瘀血闭阻证有良好的疗效。

Objective： To compare the clinical effects of Kidney-Tonifying and Blood-Activating Prescription on permenopausal and postmenopausal knee osteoarthritis. Methods： Totally 76 patients with permenopausal knee osteoarthritis treated in the department of orthopedics in this hospital between January 2014 and September 2015 were as observation group A, and 95 patients with post- menopausal knee osteoarthritis were as observation group B. Both groups were given Kidney-Tonifying and Blood-Activating Pre- seription for the treatment. The aetivity ranges, improvements of VAS and therapeutic effects of different syndromes were com- pared between tile two groups. Results： The differences of activity ranges and VAS of both groups between before treatment and after treatment trod statistical significance （ P 〈 O. 05 ） ; the differences between the two groups had no statistical signifieance （ P 〉 0.05 ）. The therapeutic effects on the TCM symptoms indicated that there was no significant difference between syndrome of liver and kidney deficiency and syndrome of static blood blockage （ P 〉 0.05 ） ; the therapeutic effects on these two syndrome were superior to that on wind-cold-damp arthralgia （P 〈 0.05）. Conclusion ： Kidney-Tonifying and Blood-Activating Prescription has excellent therapeutic effects on permenopausal and postmenopausal knee osteoarthritis.