头孢西丁和复方甘草口服溶液联用致双硫仑反应

Disulfiram reaction caused by treatment with cefoxitin combined with compound glycyrrhiza oral solution

1例81岁女性患者因肺部感染给予头孢西丁2 g静脉滴注.输注结束后1.5 h,患者因咳嗽自行服用复方甘草口服溶液 10 ml,约10 min后出现胸闷、呼吸困难、面部潮红、多汗,四肢乏力和皮疹,考虑发生双硫仑反应.给予地塞米松10 mg静脉滴注、持续低流量吸氧,约30 min后患者症状好转,2 h后患者不适症状消失.

An 81-year-old female patient with pulmonary infection was given cefoxitin 2 g by intravenous drip.After 1.5 hours of treatment, the patient self-medicated with compound glycyrrhiza oral solution 10 ml for cough.About 10 minutes later, she experienced chest tightness, dyspnea, facial flushing, hyperhidrosis, weakness of limbs and rash.Disulfiram reaction was considered.Intravenous dexamethasone 10 mg and continuous low flow oxygen were given.About 30 minutes later, the patient＆#39;s condition improved.After 2 hours, the symptoms disappeared.