中药调周期结合维生素B6治疗高催乳素血症临床观察

Clinical Observation on the Treatment of Traditional Chinese Medicine with Vitamin B6 in Treating Hyperprolactinemia

目的:研究采用中药调整月经周期结合维生素B6治疗高催乳素血症患者的临床疗效。方法:将2014年1月—2016年1月在安庆市中医医院中医妇科确诊为高催乳素血症的90例患者,随机分为中西药结合组(45例)和西药组(45例),中西药结合组应用中药汤剂调整月经周期结合维生素B6治疗,西药组给予甲磺酸溴隐亭片治疗。2组疗程均为3个月。观察2组治疗前后及停药3个月后的中医症候积分和泌乳素(PRL)治疗前后的变化情况。结果:中西药结合组的有效率为91.11%,西药组的有效率为75.56%,有明显差异。2组疗法均能降低PRL,但停药3个月后2组血清PRL值有显著差别,而且中西药结合组在改善中医证候上明显优于西药组。结论:中药调周期结合维生素B6能有效降低PRL,并对高催乳素血症的临床症状有显著的改善作用,并且作用持久,有效地规避了甲磺酸溴隐停带来的副作用,值得临床推广。

Objective： To study the clinical effect of using traditional Chinese medicine to adjust the menstrual cycle combined with vitamin B6 in the treatment of hyperprolactinemia patients. Methods： 90 patients with hyperprolactine- mia who were diagnosed as hyperprolactinemia in Anqing City Traditional Chinese Medicine Hospital from January 2014 to January 2016 were randomly divided into four groups： Chinese and western medicine group （45 cases） and western medicine group （45 cases）. Chinese medicine decoction to adjust the menstrual cycle combined with vitamin B6 treatment method was used in the combination of Chinese and Western medicine group. Western medicine group was given methanesulfonic acid bromocriptine tablets treatment. 2 groups of treatment were 3 months. The changes of TCM syndrome scores and prolactin （PRL） before and after treatment and 3 months after the treatment were observed. Results： The effective rate of the combination group was 91.11%, the effective rate of the western medicine group was 75.56%, and there was significant difference. The levels of PRL in the two groups were significantly different from those in the control group （P〈0.05）, but there was no significant difference between the two groups （P〉0.05）. Conclusion： The combination of traditional Chinese medicine and vitamin B6 can effectively reduce the PRL, and the clinical symptoms of hyperprolactinemia have a significant improvement, and the role of lasting and effective to avoid the side effects of methanesulfonic acid halo, worthy of clinical promotion.