屋尘螨变应原特异性免疫治疗195例儿童哮喘的临床疗效分析

Clinical evaluation of specific immunotherapy in 195 asthmatic children with house dust mite allergen

目的评价标准化屋尘螨变应原特异性免疫治疗(SIT)对过敏性哮喘患儿的临床疗效。方法选择在本院门诊就诊的过敏性哮喘患儿195例为研究对象,将所有患儿通过计算机随机分为对照组(108例)和干预组(87例),对照组采用常规治疗,干预组加用标准化屋尘螨过敏原制剂治疗。比较2组哮喘患儿的血清中免疫球蛋白(IgE、IgG4)的浓度变化、肺功能、哮喘症状评分情况。结果干预组的IgE的浓度下降明显低于对照组(P<0.05);干预组患儿的IgG4浓度明显高于对照组(P<0.05);肺功能、哮喘的症状评分、哮喘的控制等情况以及过敏性哮喘的有效治疗情况也明显改善。结论屋尘螨特异性免疫治疗过敏性哮喘患儿是有效的。

Objective To evaluate the effectiveness and adverse reactions of specific immunotherapy （SIT） with standardized house dust mite allergen in allergic asthmatic children. Methods Totally 195 children with allergic asthma in pediatric clinic of our hospital were divided into 2 groups： the control group （108 kids） received conventional treatment, and the intervention group （87 kids） supplemented with house dust mite sublingual drops besides conventional treatment. The serum immunoglobulin （IgE and [gG） concentration changes, the lung function, symptom score of allergic asthma, and effective treatment of the occurrence of adverse events were compared in the 2 subgroups. Results After the administration of house dust mite drops, serum immunoglobulin （IgE） concentration of the SIT group was decreased （P 〈 0.05）, and serum immunoglobulin （IgG） level was increased significantly. The lung function and asthma symptom scores were also improved. All differences compared with the control group had statistical significance （P 〈 0.05）. Meanwhile, the course of treatment and the incidence of adverse events were significantly reduced. Conclusion The SIT of house dust mite in allergic asthmatic children shows safer and better clinical efficacy.