参芪扶正注射液联合CEF方案治疗乳腺肿瘤的临床分析

Shenqifuzheng injection combined with CEF in the treatment of breast cancer

目的 观察乳腺肿瘤患者化学治疗期间配合参芪扶正注射液对免疫功能及造血功能的影响.方法 收集2014年8月至2016年8月解放军沈阳军区总医院肿瘤科98例乳腺肿瘤患者术后采用CEF化学治疗方案（环磷酰胺、表阿霉素、氟尿嘧啶）的临床资料,分为观察组（50例）与对照组（48例）.对照组采用CEF方案治疗,观察组在对照组基础上,联合参芪扶正注射液治疗.比较两组患者化学治疗前后外周血血象及T细胞亚群的变化情况.结果 观察组化学治疗后白细胞、血红蛋白及血小板均略降低,差异无统计学意义（P〉0.05）,而对照组化学治疗后白细胞、血红蛋白及血小板降低明显,差异有统计学意义（P〈0.05）;观察组与对照组化学治疗前后CD4、CD8及CD4/CD8变化明显,观察组均显著提升,而对照组均显著下降（均P〈0.05）.结论 乳腺肿瘤患者化学治疗联合参芪扶正注射液可提高免疫功能、减轻骨髓抑制.

Objective To observe the effect of Shenqifuzheng injection on immune and hematopoi-etic function in patients with breast cancer during chemotherapy. Methods A retrospective study was per-formed on 98 cases of breast cancer who were admitted from August 2014 to August 2016. Patients who re-ceived postoperative CEF chemotherapy（ cyclophosphamide, pharmorubicin, fluorouracil） were divided into two the observation group（n=50）and the control group（n=48）. Patients in the control group were treated with CEF, patients in the observation group were added with Shenqifuzheng injection on the basis of the control group. The changes of peripheral blood cells and T cell subsets between the two groups before and after chemotherapy were compared. Results The white blood cell, hemoglobin and platelet in the observa-tion group before and after chemotherapy were slightly reduced, and the differences were not statistically significant（P〉0. 05）, the white blood cells, hemoglobin and platelet in the control group reduced signifi-cantly after chemotherapy, and the differences were statistically significant （ P 〈0. 05 ）;CD4, CD8 and CD4/CD8 in the observation group and the control group were obviously changed before and after chemo-therapy, data in the observation group was significantly increased, while in the control group was signifi-cantly reduced（all P〈0. 05）. Conclusion Chemotherapy combined with Shenqifuzheng injection can im-prove immune function and reduce bone marrow suppression in patients with breast cancer.