外周5-羟色胺调控能量代谢的研究进展

Advance in the regulation of energy metabolism by peripheral serotonin

5-羟色胺(5-hydroxytryptamine,5-HT)是调节机体生命活动的重要分子。在肥胖等代谢性疾病的治疗中,通过调控中枢5-HT系统抑制食欲的传统模式存在较大的局限性。近年来,有关外周5-HT系统调节能量代谢的研究取得了较大进展。研究发现,外周5-HT参与调节脂肪细胞脂肪形成与能量消耗、胰岛β细胞胰岛素分泌及肝脏糖原合成等过程。本文就5-HT对外周重要能量代谢调节组织的调控作用进行综述,以期为代谢综合征的干预提供新思路。

Serotonin （5-hydroxytryptamine, 5-HT） is an endogenous molecule playing key roles in life activity. In the treatment of metabolic diseases such as obesity, the traditional paradigm of appetite suppression by serotonin in the central nervous system has some limitations. In recent years, great progress has been made in the study of the regulation of energy metabolism by peripheral serotonin system. Recent studies revealed that peripheral serotonin plays an important role in regulation of adipogenesis and energy expenditure in adipose tissues, insulin secretion in pancreatic β-cell and glycogen synthesis in liver, etc. This review summarizes the recent advances in the function of serotonin in the peripheral organs of energy metabolism. We propose that peripheral serotonin system may serve as an attractive new therapeutic target for the treatment of metabolic diseases in the near future.