微囊泡与糖尿病视网膜病变相关性研究现状

Recent research progress between the microvesicle and diabetic retinopathy

微囊泡（MV）是机体各种细胞在正常或病理状态下从细胞膜表面直接出芽脱落形成的小囊泡样物质，可通过多种途径激活凝血、炎症反应并影响血管内皮细胞功能。MV可介导内皮细胞损伤、血栓形成、促进新生血管形成等病理过程在糖尿病视网膜病变（DR）发病机制中发挥重要作用；血浆MV水平可能成为监测DR发生发展的有效指标。进一步深入研究MV形成机制、组成成分及其在DR血管病变中的作用，探讨MV作为反映DR进展与程度的新的生物标志物和药物治疗靶点的可能性，将为DR血管病变诊断治疗开辟新的前景。

Microvesicles （MVs） is small membrane vesicles released from different cell types under different conditions. Studies have shown that MVs may mediate vascular inflammation, angiogenesis, and other pathological processes. MVs may play an important role in the pathogenesis of diabetic retinopathy （DR） by mediating endothelial cell injury, thrombosis and neovascularization. The plasma MV level may be an effective parameter to monitor the development of DR. This article will summarize the research progress of the relationship between MVs and DR in recent years.