α1-微球蛋白、C-反应蛋白、D-二聚体联合检验在妊娠期高血压疾病诊疗中的意义

Significance of α1-microglobulin,C-reactive protein and D-dimer in diagnosis and treatment of hypertensive disorder complicating pregnancy

目的观察分析妊娠期高血疾病孕妇血清中α1-微球蛋白(α1-MG)、C-反应蛋白(CRP)、血浆D-二聚体(D-D)的变化规律及其临床意义。方法回顾性分析2015年10月-2016年12月该院妊娠期高血压疾病孕妇52例为研究组,同期健康孕妇及未孕妇女82例为对照组。采用全自动生化分析仪测定各组孕妇血清中α1-MG、CRP含量,采用全自动血凝仪测定各组孕妇血浆D-D含量。结果研究组孕妇血清中的α1-MG、CRP、D-D浓度均高于对照组,且子痫孕妇要高于子痫前期孕妇,重度子痫前期孕妇高于轻度子痫前期孕妇。结论妊娠期高血压疾病孕妇血清α1-MG、CRP、血浆D-D含量随病情加重而增高。动态监测孕妇血清中α1-MG、CRP、血浆D-D浓度可作为妊娠期高血压疾病诊断、病情监控及防治并发症保护母婴安全的良好指标。

Objective To observe and analyze the change regularity of serum α1- microglobulin （α1- MG ）, C-reactive protein （CRP） and plasma D-dimer （D-D） in pregnant women with hypertensive disorder complicating pregnancy （HDCP） and the clinical signifi- cance. Methods A total of 52 pregnant women with HDCP were enrolled in this study （ study group） , 82 healthy pregnant women and non -pregnant women were selected as control group. The levels of α1-MG and CRP in serum of pregnant women were determined by automatic biochemical analyzer. The contents of plasma D-direct were detected by automatic coagulometer. Results The levels of serum α1 -MG and CRP in study group were higher than those in control group, the levels of serum α1-MG and CRP in pregnant women with eclampsia were higher than those of pregnant women with preeclampsia, the levels of serum α1 -MG and CRP in pregnant women with severe preeclampsia were higher than those of pregnant women with mild preeclampsia. Conclusion The levels of serum α1 -MG, CRP and plasma D-D in pregnant women with HDCP increased with aggravation of the disease. Dynamic monitoring of serum α1 -MG, CRP and plasma D-D concen- trations can be used as good indexes of HDCP diagnosis, disease monitoring and prevention of complications to protect mothers and children.