二甲双胍对直肠癌术后患者预后的影响

Effect of metformin on prognosis of patients with rectal cancer after operation

目的探讨二甲双胍对直肠癌术后患者预后的影响。方法 96例直肠癌患者,根据临床分期分为对照组(A组,41例)和放化疗组(B组,55例),A组、B组再分为无糖尿病组(A1组、B1组)、糖尿病未用二甲双胍组(A2组、B2组)和糖尿病使用二甲双胍组(A3组、B3组)。A组患者行手术治疗,B组患者行放化疗及手术治疗,术后随访观察,计算术后总生存率(OS)、无进展生存率(PFS)和局部复发率(LRR)。结果A1、A2、A3组LRR和PFS比较无统计学差异(P>0.05)。B3组PFS高于B1、B2组(P<0.05),B1、B2、B3组LRR和OS比较无统计学差异(P>0.05)。结论二甲双胍能改善行放化疗的直肠癌患者术后的预后。

Objective To investigate the effect of metformin on the prognosis of patients with rectal cancer after operation.Methods A total of 96 patients with rectal cancer was divided into two groups of A（control group,41cases）and B（with radiochemotherapy,55cases）.Each group was divided into non-diabetes mellitus group（group A1,group B1）,diabetes mellitus without metformin group（group A2,group B2）and diabetes mellitus with metformin group（group A3,group B3）.The patients in group A were treated with surgical operation and those in group B were treated with radiotherapy and chemotherapy before surgical operation.The patients were followed-up.The overall survival（OS）,progression free survival（PFS）and local recurrence（LRR）were calculated.Results There were no significant differences in LRR and PFS in groups of A1,A2 and A3（P〉0.05）.PFS was higher in group B3 than that in groups of B1 and B2（P〈0.05）.There were no significant differences in LRR and OS in groups of B1,B2 and B3（P〉0.05）.Conclusion Metformin can improve the postoperative prognosis of patients with rectal cancer treated with radiochemotherapy.