胰岛素样生长因子1受体及其通路在原发性肝癌中的机制及进展

Research advances in insulin-like growth factor 1 receptor and its pathway in diagnosis and treatment of primary liver cancer

胰岛素样生长因子1受体(IGF-1R)的生物学功能主要表现为形成并维持细胞的转化表型,参与细胞增殖、分化,抑制细胞的凋亡。除此之外,IGF-1R对细胞周期具有调节作用,与表皮生长因子、血小板衍生生长因子共同作用,介导细胞周期从G1期进入S期。过度表达的IGF-1R己经成为原发性肝癌影像诊断及定位治疗的热点靶蛋白之一。抑制IGF-1R的表达或功能可有效控制肿瘤细胞生长和转移,并增强其对化疗、放疗的敏感性。综述了IGF-1R及其通路在原发性肝癌诊断及治疗中的作用及意义。

The main biological functions of insulin - like growth factor 1 receptor （ IGF - 1 R） include formation and maintenance of transformed cell phenotype, involvement in cell proliferation and differentiation, and inhibition of cell apoptosis. In addition, IGF - 1 R regulates cell cycle and works with epidermal growth factor and platelet - derived growth factor to mediate cells to enter S phase from G1 phase. Overexpressed IGF - 1 R has become one of the target proteins for diagnostic imaging and localization therapy for primary liver cancer. Inhibition of the expression or function of IGF - 1 R can effectively control the growth and metastasis of tumor cells and enhance their sensitivity to chemotherapy and radiotherapy. This article reviews the role and significance of IGF - 1 R and its pathway in the diagnosis and treatment of primary fiver cancer.