不同负荷游泳运动对大鼠部分免疫指标的影响

Effect of Different Load Swimming on some Immunologic Indexes of Rats

目的:探讨不同负荷运动后,大鼠T淋巴细胞活性、NK细胞毒活性、IL-1和IL-2活性指标的变化。方法:采用完全随机化的方法,按性别将SD大鼠(雄性30只,雌性30只)随机分成雄性对照组(N=10),雄性中等负荷运动组(N=10),雄性力竭运动组(N=10);雌性对照组(N=10),雌性中等负荷运动组(N=10),雌性力竭运动组(N=10)。取材后,测定大鼠脾脏T淋巴细胞活性、NK细胞毒活性和IL-2活性,大鼠腹腔巨噬细胞IL-1活性。结果:T淋巴细胞活性、NK细胞毒活性、IL-1和IL-2的变化:中等负荷运动组比对照组增强,而力竭运动组比对照组降低,皆存在显著性差异。结论:中等负荷运动可提高大鼠的免疫功能;力竭运动可降低大鼠的免疫功能。

Objective： To explore the difference in these four indexes： the change of T lymphocyte activity, cytotoxic activity of NK cells and IL - 1 activity and IL - 2 activity of the male rats and female rats after the different exercise load, and to discuss the change of the indexes. Methods： using complete randomized methos, SD rats by gender （male 30, female 30 ） were divided into male group （ N = 10 ） , the male of moderate load exercise group （ N = 10）, the male of exhaustive exercise group {N = 10）;female control group {N = 10）, female moderate load exercise group （ N = 10） , female exhaustive exercise group （ N = 10）. The determination of rat spleen T lymphocyte activity, eytotoxic activity of NK cells and IL - 2 activity, IL - 1 activity of rat peritoneal macrophages. Results ： the changes of T lymphocyte activity, activity of NK cells, IL - 1 and IL -2. ： the moderate load group increased than the control group, and the exhausted group decreased than the control group, there was significant difference. Conclusion： moderate load exercise can strengthen the immune function of rats;exhaustive exercise can weaken the immunologic function of rats.