调肝理脾法治疗非酒精性脂肪肝临床观察

Clinical observation of regulating liver and spleen method in the treatment of non-alcoholic fatty liver disease

目的观察自拟调肝理脾法治疗非酒精性脂肪肝的临床效果。方法 60例患者均来自2015年8月~2016年8月北京中医医院顺义医院脾胃病科门诊及住院患者,采用随机单盲法将其分为治疗组和对照组,各30例。治疗组给予调肝理脾基本方加减联合控制饮食、运动等基础疗法,对照组仅给予控制饮食、运动治疗。观察两组治疗前后症状、转氨酶、体重指数等变化。结果治疗组总有效率为93.33%,对照组总有效率为56.67%,两组比较差异有统计学意义(P<0.05)。两组治疗后症状积分、谷丙转氨酶、谷草转氨酶、体重指数均较治疗前显著降低(P<0.05),且治疗组治疗后上述指标显著低于对照组,差异有统计学意义(P<0.05)。结论自拟调肝理脾方治疗肝郁脾虚证非酒精性脂肪肝的效果显著,能明显减轻临床症状,改善肝功能,提高生活质量。

Objective To observe the clinical effect of self-made regulating liver and spleen method in the treatment of non-alcoholic fatty liver disease. Methods Sixty patients were all from Outpatient and Inpatient Department of Spleen and Stomach Diseases of Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine from August 2015 to Au- gust 2016, they were randomly divided into the treatment group and control group by single-blind method, with 30 cases in each group. The treatment group was given modified basic prescription of regulating liver and spleen combined with other basic therapies, such as diet control and exercise, while the control group was only given diet control and exer- cise. The changes of symptoms, transaminases and body mass index of the two groups before and after treatment were observed. Results The total effective rate of the treatment group was 93.33%, which of the control group was 56.67%, the difference between the two groups was statistically significant （P 〈 0.05）. The symptom scores, alanine transami- nase, aspartate aminotransferase, body mass index of the two groups after treatment were all significantly lower than those before treatment （P 〈 0.05）, and the indexes above in the treatment group after treatment were all lower than those of control group, the differences were statistically significant （P 〈 0.05）. Conclusion The clinical effect of self- made regulating liver and spleen prescription in the treatment of non-alcoholic fatty liver disease patients with type of liver stagnation and spleen deficiency is significant, which can significantly reduce clinical symptoms, improve liver function and quality of life.