气滞血瘀证对慢性前列腺炎/盆腔疼痛综合征患者UPOINT因子表型分布的影响

Influence of qi stagnation and blood stasis on the distribution patterns of positive UPOINT domains in patients with chronic prostatitis/chronic pelvic pain syndrome

目的研究中医证型(气滞血瘀证)对慢性前列腺炎/盆腔疼痛综合征(CP/CPPS)患者临床表型系统(UPOINT)阳性因子表型分布的影响。方法在2015年6月~2016年8月于广州中医药大学附属广东省中医院珠海医院男科门诊就诊的CP/CPPS患者中,选取符合气滞血瘀证诊断标准的CP/CPPS患者90例设为A组;另在所有患者中(剔除已纳入A组者)随机选取CP/CPPS患者90例设为B组。分析两组患者UPOINT阳性因子个数与美国国立卫生研究院慢性前列腺炎症状评分指数表(NIH-CPSI)评分间的相关性,观察两组患者UPOINT阳性表型因子分布差异。结果两组UPOINT阳性因子个数均与NIH-CPSI评分呈正相关(均P<0.01);两组患者UPOINT阳性表型因子总体分布的差异有高度统计学意义(P<0.01),其中A组O、T因子阳性率均高于B组(P<0.05、P<0.01),A组U因子阳性率低于B组(P<0.01)。结论中医证型(气滞血瘀证)可对CP/CPPS患者UPOINT表型分布产生影响,并对其中的O、T阳性因子影响较大。

Objective To study the influence of syndrome of TCM （qi stagnation and blood stasis） on the distribution patterns of positive clinical phenotyping system （UPOINT） domains in patients with chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS）. Methods During the patients with CP/CPPS treated in Department of Andrology, Zhuhai Hospital of Guangdong TCM Hospital Affiliated to Guangzhou University of Chinese Medicine from June 2015 to Au- gust 2016, 90 patients with CP/CPPS met with syndrome of qi stagnation and blood stasis were chosen as group A, and 90 patients with CP/CPPS were randomly selected as group B from all the patients but those in group A. The correla- tion of national institutes of health-chronic prostatitis symptom index （NIH-CPSI） scores and positive UPOINT domains between the two groups was analyzed, and the distribution patterns of positive UPOINT domains in the two groups were observed. Results The correlation between UPOINT domains and NIH-CPSI scores had statistically significant differ- ences in the two groups （P 〈 0.01）. The distribution patterns of positive UPOINT domains between the two groups had statistically significant differences （P 〈 0.01）, among which, the positive rates of O and T domains in group A were higher than those in group B （P 〈 0.05, P 〈 0.01）, the positive rate of U domain in group A was lower than that in group B （P 〈 0.01）. Conclusion Syndrome of TCM （qi stagnation and blood stasis） can affect distribution patterns of positive UPOINT domains and significantly affect O and T domains.