二仙汤及其拆方治疗卵巢早衰的实验研究进展

Experimental research progress of Erxian decoction and its disassembled prescriptions in treatment of premature ovarian failure

近年来,卵巢早衰发病率呈逐年上升趋势。现代医学主要是以激素替代疗法加以治疗,临床效果一般且副作用大。传统医学认为此病主要是年未老,冲任已衰,天癸已竭,肾中精气的衰少,从而诱发卵巢早衰。二仙汤主要有温补肾阳、改善体内雌激素水平的作用。在临床治疗卵巢早衰中发挥着重要的作用。本文通过促性腺激素、下丘脑生殖调节激素、下丘脑—垂体—卵巢轴以及卵巢颗粒细胞水平综述了近几年来关于二仙汤及其拆方在治疗卵巢早衰方面的实验研究进展。

In recent years, the incidence of premature ovarian failure rate has increased. Modern medicine is mainly treated with hormone replacement therapy, the clinical effect is modest and the side effect is big. The traditional Chinese medicine considers the disease is mainly about age is not old, but the Chong-Ren has been weak, Tiangui has dried up, Shen essence and qi is reduced, and premature ovarian failure is induced. Erxian decoction is mainly Tonifying Kidney Yang, improve the level of estrogen in vivo. Play an important role in the clinical treatment of premature ovarian failure. In this paper, hypothalamic gonadotropin, reproductive hormones regulation of the hypothalamic pituitary ovarian axis and granulosa cell level in recent years was reviewed on Erxian decoction and its disassembled prescriptions in the treatment of premature ovarian failure in experimental study.