保妇康栓与干扰素栓治疗宫颈人乳头瘤病毒感染疗效对比

Efficacy Comparison of Baofukang Suppository and Interferon Suppository in Treating Cervical Human Papilloma Virus Infection

目的比较保妇康栓与干扰素栓治疗宫颈人乳头瘤病毒(HPV)感染的疗效。方法选择2015年4月至2016年4月宫颈HPV感染患者96例,随机分为两组,各48例。干扰素栓组采用干扰素栓治疗,保妇康栓组采用保妇康栓治疗。比较两组患者宫颈HPV感染控制率,临床症状缓解时间,宫颈HPV转阴时间,以及治疗前后HPV-DNA,C反应蛋白(CRP)、白细胞介素10(IL-10)、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)等水平的差异。结果治疗后,保妇康栓组患者宫颈HPV感染控制率高于干扰素栓组,临床症状缓解时间、宫颈HPV转阴时间短于干扰素栓组(P<0.05);两组患者HPV-DNA水平均较治疗前明显降低,且保妇康栓组降幅更大(P<0.05);两组患者血清中CRP,IL-10,TNF-α,IL-1β水平均较治疗前明显改善,且保妇康栓组改善幅度更大(P<0.05)。结论保妇康栓治疗宫颈HPV感染疗效优于干扰素栓,可有效降低HPV-DNA水平及机体炎性因子水平,促进HPV转阴和症状消失,疗效确切,值得推广。

Objective To compare the clinical efficacy of Baofukang Suppository and Interferon Suppository in treating cervical human papilloma virus（HPV）infection. Methods Totally 96 patients with cervical HPV infection from April 2016 to April 2017 in the hospi-tal were randomly divided into two groups,48 cases in each group. The Interferon Suppository group was treated with Interferon Supposi-tory,while the Baofukang Suppository group was treated with Baofukang Suppository. The control rate of the HPV infection;relief time of clinical symptoms,clearance time of cervical HPV,and the levels of serum HPV-DNA,CRP,IL-10,TNF-α,IL-1β before and after treatment were compared in the two groups. Results After treatment,the control rate of HPV infection in the Baofukang Suppository group was significantly higher than that in the Interferon Suppository group,the relief time of clinical symptoms and clearance time of cervical HPV in the Baofukang Suppository group was significantly shorter than those in the Interferon Suppository group（P 〈 0. 05） . Compare with before treatment,the level of HPV-DNA in the two groups had significantly improved after treatment,and the Baofukang Suppository group improved more greatly（P 〈 0. 05）. Conclusion The efficacy of Baofukang Suppository is superior to Interferon Sup-pository in the treatment of cervical HPV infection,which can effectively reduce the level of HPV-DNA,inflammation,promote HPV and negative symptoms disappear,it is efficacy and worthy of clinical promotion.