凝血及纤溶功能指标对妊高征的联合诊治价值

The value of blood coagulation and fibrinolysis in the diagnosis and treatment of pregnancy induced hypertension

目的分析血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D二聚体等凝血功能和纤溶功能指标对妊娠高血压综合征(妊高征)患者的临床诊治价值。方法选取100例妊娠高血压综合征患者、50名足月健康孕妇以及50名体检健康女性作为研究对象,分别纳入妊高征组、正常妊娠组和健康对照组,对比各组凝血功能和纤溶功能指标差异。结果与正常妊娠组和健康对照组比,妊高征组PT、APTT、TT明显缩短,FIB和D二聚体等纤溶功能指标明显升高,差异有统计学意义(P<0.05)。结论 PT、APTT,TT、FIB和D二聚体等凝血功能和纤溶功能指标,可作为临床诊断、治疗和预防妊娠高血压综合征的参考指标。

Objective To investigate clinical diagnosis value of plasma prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fibrin original（FIB）and D dimer,the function index of blood coagulation system and fibrinolysis system in pregnancy induced hypertension syndrome（PIH）. Methods 100 patients with PIH,50 health pregnant women and 50 healthy women in our hospital were selected as the pregnancy induced hypertension group,the normal group and the control group. the function index of blood coagulation system such as PT,APTT,TT,FIB and D dimer and the index of fibrinolysis system of each group were compared. Results PT,APTT and TT levels in the pregnancy induced hypertension group were significantly lower than those of the other two groups;the FIB and D dimer levels of the pregnancy induced hypertension group were significantly higher than those of the normal group and the control group;the differences were statistically significant（P〈0.05）. Conclusion PT,APTT,TT,FIB and D dimer function indexes of blood coagulation system and fibrinolysis system were closely related to the pregnancy induced hypertension syndrome,and could be used for diagnosis,treatment and prevention of the pregnancy induced hypertension.