慢乙肝抗HBV病毒治疗的现状和研究进展

Current status and research progress of the treatment of chronic hepatitis B with anti HBV virus

乙型肝炎疫苗的接种降低了乙肝病毒的感染。然而,乙型肝炎仍是临床上常见的疾病之一,抗病毒治疗在控制慢性乙型肝炎病毒感染和预防疾病进展起着重要的作用。目前抗病毒药物主要为干扰素和核苷(酸)类似物两大类,由于乙型肝炎的发病机制不祥,在临床上慢性乙型肝炎的治疗未达到理想疗效,本文主要针对抗病毒药物的使用现状及特殊人群抗病毒用药情况,指导临床用药,提高临床疗效。

The hepatitis B vaccine inoculation reduces the hepatitis b virus infection. However,hepatitis B is still one of the common diseases;hepatitis B antiviral treatment plays an important role in control and prevention of chronic hepatitis B virus.Current antiviral drugs mainly are interferon and nucleoside analogues（acid）two categories. Due to the unclear pathogenesis of hepatitis B,the clinical treatment of chronic hepatitis B does not achieve the desired effect. This paper focuses on the discussion of the current suitation of the use of antiviral drugs and antiviral medications in some special populations,and provides guideline for clinical drug use to improve the clinical curative effect.