脑梗死发病前期不同时间段感染与脑梗死的相关性研究

Correlation between recent infection and onset of cerebral infarction

目的探讨不同时间的前期感染与脑梗死发病的相关性及其对脑梗死发病的影响。方法选取2013年1月-2016年6月收治脑梗死患者462例,调查分析患者发病前30d内感染情况。结果 462例患者前期感染率为28.57%;其中≤50岁、>50~≤60岁、>60~≤70岁、>70岁的患者前期感染率分别为16.67%、27.22%、30.57%、29.41%,男性、女性患者前期感染率分别为29.54%、27.27%,不同年龄段及不同性别患者前期感染率比较差异无统计学意义;脑梗死发病前1~3、4~7、8~15、16~30d时前期感染构成比分别为23.49%、58.33%、9.85%、8.33%;有前期感染的脑梗死患者神经功能缺损评分、脑梗死病灶大小分别为(27.86±8.47)分、(8.44±2.25)cm3,无前期感染的脑梗死患者分别为(20.21±6.39)分、(5.67±2.12)cm3,差异有统计学意义(P<0.05);神经功能缺损评分、脑梗死病灶大小在发病前1~3d前期感染脑梗死患者分别为(27.85±8.44)分、(8.49±2.30)cm3,发病前4~7d时分别为(27.90±8.50)分、(8.30±2.56)cm3,发病前时8~15d分别为(22.18±8.03)分、(6.11±1.78)cm3,发病前16~30d分别为(21.87±8.10)分、(5.80±1.58)cm3,差异有统计学意义(P<0.05),其中1~3、4~7d时间段前期感染患者神经功能缺损评分及脑梗死病灶大小大于8~15、16~30d的患者(P<0.05)。结论前期感染是导致脑梗死发生的危险因素,尤其是发病前7d内的感染与脑梗死关系最为密切。

OBJECTIVE To explore the relationship between the recent infection in different time periods and the onset of cerebral infarction and observe the influence on the onset of cerebral infarction.METHODS A total of 462 patients with cerebral infarction who were treated in the hospital from Jan 2013 to Jun 2016 were enrolled in the study.The prevalence of infection was investigated within 30 days before the onset of disease.RESULTS The incidence rate of recent infection was 28.57% among the 462patients;the incidence rate of recent infection was16.67%in the patients aged no more than 50 years old,27.22%in the patients aged between 50 and 60years old,30.57%in the patients aged between 60 and 70years old,29.41%in the patients aged more than 70 years old;the incidence rate of recent infection was 29.54%in male patients,27.27%in female patients;there was no significant difference in the incidence rate of recent infection among the patients in different age groups or between the male patients and the female patients.The proportion of the patients with recent infection was 23.49% at 1-3days before the onset of cerebral infarction,58.33%at 4-7days before the onset,9.85%at 8-15 days before the onset,8.33%at 16-30 days before the onset.The neural function defect scale score of the cerebral infarction patients with recent infection was（27.86±8.47）points,the cerebral infarction patients without recent infection（20.21±6.39）points;the size of cerebral infarction lesion of the patients with recent infection was（8.44±2.25）cm3,the patients without recent infection（5.67±2.12）cm3,and there was significant difference（P〈0.05）.The neurologic function defect scale score of the cerebral infarction patients with recent infection was（27.85±8.44）points at 1-3days before the onset,（27.90±8.50）points at 4-7days before the onset,（22.18±8.03）points at 8-15 days before the onset,（21.87±8.10）points at 16-30 days before the onset;the size of cerebral infarction lesion of the patients with recent infection was（8.49±2.30）cm3 at 1-3days before the onset,（8.30±2.56）cm3 at 4-7days before the onset,（6.11±1.78）cm3 at 8-15 days before the onset,（5.80±1.58）cm3 at 16-30 days before the onset,and there was significant difference（P〈0.05）;the neural function defect scale score and size of cerebral infarction lesion of the patients with recent infection were greater at 1-3days,4-7days before the onset than at 8-15 days,16-30 days before the onset（P〈0.05）.CONCLUSIONThe recent infection is the risk factor for the onset of cerebral infarction,and the infection within 7days before the onset shows the closest association with the cerebral infarction.