雷贝拉唑三联疗法在萎缩性胃炎并发幽门螺杆菌感染患者中的应用效果

Effect of rabeprazole triple therapy on treatment of atrophic gastritis patients complicated with Helicobacter pylori infection

目的探讨雷贝拉唑三联疗法在萎缩性胃炎并发幽门螺杆菌(Hp)感染患者中的应用效果。方法 164例萎缩性胃炎并发Hp感染患者随机分为三联疗法组和对照组,每组各82例;对照组采用雷贝拉唑进行治疗,三联疗法组采用雷贝拉唑、阿莫西林与呋喃唑酮三联疗法进行治疗,对比两组萎缩性胃炎并发Hp感染患者疗效、血清丙二醛(MDA)水平、血清超氧化物歧化酶(SOD)水平及谷胱甘肽过氧化物酶(GSH-PX)活性、不良反应。结果治疗前,两组萎缩性胃炎并发Hp感染患者血清MDA、SOD、GSH-PX水平差异无统计学意义;治疗后,两组萎缩性胃炎并发Hp感染患者血清MDA水平均显著降低,SOD、GSH-PX水平均显著升高(P<0.01);与对照组相比,三联疗法组患者血清MDA水平显著低于对照组,SOD、GSH-PX水平均显著高于对照组(P<0.05);三联疗法组患者治疗总有效率为95.1%,显著高于对照组的82.9%,差异有统计学意义(P<0.01);三联疗法组患者治疗后Hp转阴率为92.7%,显著高于对照组的79.3%,差异有统计学意义(P<0.05);三联疗法组患者治疗后不良反应发生率为7.3%,对照组为8.5%,两组比较差异无统计学意义。结论雷贝拉唑三联疗法能够显著提升萎缩性胃炎并发Hp感染患者的治疗有效率及Hp转阴率,可能与MDA水平降低,SOD、GSH-PX水平均升高有关。

OBJECTIVE To explore the effect of rabeprazole triple therapy on treatment of atrophic gastritis patients complicated with Helicobacter pylori infection.METHODS A total of 164 atrophic gastritis patients complicated with H.pylori infection were randomly divided into the triple therapy group and the control group,with 82 cases in each group.The control group was treated with rabeprazole,while the triple therapy group was given the triple therapy of rabeprazole,amoxicillin,and furazolidone.The curative effect,serum malondialdehyde（MDA）level,serum superoxide dismutase（SOD）level,serum glutathione peroxidase（GSH-PX）activity,and adverse reactions were observed and compared between the two groups of atrophic gastritis patients complicated with H.pylori infection.RESULTS There was no significant difference in the level of serum MDA,SOD,or GSH-PX between the two groups of atrophic gastritis patients complicated with H.pylori infection before the treatment.After the treatment,the serum MDA level of the two groups of atrophic gastritis patients complicated with H.pylori infection was significantly reduced,while the levels of SOD and GSH-PX were significantly elevated（P〈0.01）.The serum MDA level of the triple therapy group was significantly lower than that of the control group,while the levels of SOD and GSH-PX of the triple therapy group were significantly higher than those of the control group（P〈0.05）.The total effective rates of treatment of atrophic gastritis complicated with H.pylori infection was 95.1%in the triple therapy group,significantly higher than 82.9%in the control group（P〈0.01）.The negative rate of H.pylori of the atrophic gastritis patients complicated with H.pylori infection was 92.7%in the triple therapy group after the treatment,significantly higher than 79.3%in the control group（P〈0.05）.The incidence of adverse reactions in the atrophic gastritis patients complicated with H.pyloriinfection was 7.3%in the triple therapy group after the treatment,8.5% in the control group,and there was no significant difference between the two groups.CONCLUSIONThe rabeprazole triple therapy can remarkably raise the effective rate of treatment of the atrophic gastritis patients complicated with H.pylori infection and the negative rate of H.pylori,which may be associated with the reduction of MDA level and the elevation of levels of SOD and GSH-PH.