剪切力对肝脏切除术后肝窦内皮细胞的作用

Effect of shear stress on hepatic sinusoidal endothelial cells after hepatectomy

肝切除术是肝脏疾病尤其是肝脏肿瘤的重要治疗手段,并且在肝切除术后会出现肝脏血流动力学的改变.肝窦内皮细胞是肝窦毛细血管内一类特殊的内皮细胞,对血流变化十分敏感.本文就肝脏切除术后血流产生的剪切力作用于肝窦内皮细胞,从而调节肝细胞再生和肝组织恢复的作用及机制作一综述.

Hepatectomy is an important therapeutic means for hepatic diseases, especially hepatic tumors. After hepatectomy, changes in hepatic hemodynamics may occur. Hepatic sinusoidal endothelial cells, a special group of endothelial cells in sinusoidal capillaries, are very sensitive to changes in blood flow. The present study summarizes the effect of shear stress generated by blood flow after hepatectomy on hepatic sinusoidal endothelial cells with regard to the regulation of hepatocyte regeneration and recovery of hepatic tissue, as well as the underlying mechanisms.