肠道微生态与疾病

INTESTINAL MICROBIOME AND DISEASES

作为人体微生态系统的重要组成部分之一,肠道微生态辅助人体进行营养物质的转化与吸收并与多个组织、器官存在密切的相互作用,是人体健康的重要保障。近年来利用宏基因组学和生物信息学技术对不同疾病人群的肠道微生态结构和特征进行分析表明,人体健康与肠道微生态存在密切而复杂的联系。在2型糖尿病、冠心病、肥胖、结肠癌、类风湿性关节炎等诸多疾病中开展的菌群研究为其复杂机制探索提供了新的思路,也为这些疾病的预防、预警、干预和治疗提供了新方法。同时,这些实践又进一步提升了我们对肠道微生态在人体健康中发挥作用的认知。

As one of the key components of human micro-ecosystem, intestinal microorganisms have significant impacts on our health by affecting nutrient absorption and exchanging multiple information with our body. With the recent development of the metagenomics and bioinformatics technology, we have acquired substantial achievements on intestinal microorganisms and diseases （such as type 2 diabetes, coronary heart disease, obesity, colorectal cancer, rheumatoid arthritis） and their intimate and complicated impacts on our health. These studies also offer a great potential feasibility of microorganism-based applications for disease risk evaluation, early diagnosis, prevention and treatment, which enhances our understanding of their impacts on ourhealth.