2015年泸州市合江县抗结核药品不良反应分析

Drug Adverse Reaction of Anti-tuberculosis in Hejiang County of Luzhou City,2015

目的分析抗结核药物的不良反应发生情况,对不良反应的危害及其处理措施进行评价。方法选取泸州市合江县2015-04-01/2015-09-30登记治疗的223名初治患者进行随访和跟踪调查并进行分析。结果 223例患者中150例患者发生不良反应,总不良反应发生率达67.26%。不良反应类型中,主要为高尿酸血症(46.64%),其次是肝酶升高(13.90%)和皮肤瘙痒(7.17%);不良反应以轻度为主(76%);不良反应发生后,只有8.67%的患者需停用或减量结核药物。发生不良反应的150例患者采取及时有效的处理措施后治疗成功率达100%。结论抗结核药品的不良反应发生率高,但及时采取有效处理措施,患者仍能获得很好的依从性和治疗成功率。

Objective To analyze the incidence of adverse reactions of anti - TB drugs, then evaluate how harmful of adverse reaction is and its treatment measures. Methods A total of 223 newly diagnosed patients were en- rolled from April 1,2015 to September 30, 2015 in Hejiang County, where the visit and follow - up survey was conducted. Results 150 patients had adverse reactions and the total adverse reaction rate was 67.26%. Ad- verse reactions were mainly hyperuricemia （ 46.64% ）, elevated liver enzymes （ 13.90% ） and pruritus （7.17%）. Mainly adverse reactions were mild （76%）, only 8.67% of patients need to stop or reduce dose of tuberculosis drugs after that. All the 150 cases were successfully cured after timely and effective treatment.Conclusion The adverse reaction rate of anti - tuberculosis drugs was high, with the timely and effective treatment, the patients could get a good compliance and recover.