髓系细胞触发受体-1与动脉粥样硬化关系的研究进展被引量：1

Research Progress of Association between Triggering Receptor Expressed on Myeloid Cells-1 and Atherosclerosis

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摘要髓系细胞触发受体-1(TREM-1)是新近发现的免疫球蛋白超家族活化跨膜受体,能够触发和扩大炎症反应,在动脉粥样硬化(AS)的炎症机制中起重要作用。本文从TREM-1的结构特点、表达方式、配体结合、信号通路等论述其与AS发生发展及动脉斑块稳定性的关系和作用,为临床研究AS的靶向治疗提供参考和借鉴。 The triggering receptor expressed On myeloid cells-1 （TREM-1） that can trigger and expand in- flammatory response is a newly discovered activating transmembrane receptor of immunoglobulin superfamily,and it plays a key role in atherosclerosis （AS）. To provide a reference or clue for targeted therapy of AS in clinical research,this review discusses effects of TREM-1 on development of AS and artery plaque stability from its structural characteristics, expression, ligand binding, signaling pathways et al.

作者陆娇李承彬 LU Jiao LI Cheng-bin(The Second Clinical Medical College of Yangtze University ,Jingzhou 434020, Hubei Province, Chin)

机构地区长江大学第二临床医学院

出处《微循环学杂志》 2017年第2期81-84,F0003,共5页 Chinese Journal of Microcirculation

关键词髓系细胞触发受体-1 炎症反应动脉粥样硬化 Triggering receptor expressed on myeloid cells-1 Inflammatory response Atheroselerosis

分类号 R543.5 [医药卫生—心血管疾病]

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参考文献1

1戴道鹏,沈迎,张瑞岩,丁风华,陆林,陶蓉.血清可溶性髓样细胞触发受体-1水平对冠状动脉粥样斑块进展的预测价值[J].国际心血管病杂志,2016,43(5):303-306. 被引量：13

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