低分子肝素治疗小儿肾病综合征的临床效果

Clinical efficacy of low molecular heparin in children with nephrotic syndrome

目的探讨低分子肝素治疗小儿肾病综合征的临床效果。方法选取2013年2月~2017年2月我院收治的100例肾病综合征患儿,将其抽签化分组,两组各50例。在常规治疗的基础上,对照组采用常规治疗联合强的松治疗,观察组在对照组基础上采用低分子肝素治疗,比较两组患儿血肌酐清除率(Cer)、尿素氮(BUN)、血肌酐(SCr)、24 h尿蛋白、血浆白蛋白(Alb)、血总胆固醇(TC)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)水平及不良事件发生率。结果观察组患儿的Cer、BUN、SCr、24 h尿蛋白、TC水平均低于对照组,Alb水平高于对照组,患儿PT、APTT短于对照组,不良事件发生率低于对照组,差异有统计学意义(P<0.05)。结论低分子肝素治疗小儿肾病综合征效果显著,且安全性较高。

Objective To explore the Clinical efficacy of low molecular heparin in children with nephrotie syndrome. Methods 100 children with nephrotic syndrome admitted to our hospital from February 2013 to February 2017 were selected and were divided into the observation group and the control group according to the method of lottery,with 50 cases in each group.Patients in the control group were given conventional therapy and prednisone while the observation group were given low molecular heparin on the basis of the control group.The levels of Cer, BUN,SCr,24 h urine protein, Alb and TC,PT,APTT and the incidence of adverse events were compared between two groups.Results The levels of Ccr, BUN,SCr,24 h urine protein and TC of patients in the observation group were lower than those in the control group; the level of Alb was higher than that in the control group;the PT and APTT were shorter than those in the control group; the incidence of adverse events was lower than that in the incidence of adverse events,and all the differences were statistically significant （P〈0.05）.Conclusion Low molecular heparin in the treatment of children with nephrotic syn- drome is effective and safe.