炎症性肠病患者IL-6、sICAM-1及chemerin改变及与自主神经功能相关性研究

The changes of IL-6,sICAM-1 and chemerin in patients with inflammatory bowel disease and the correlation with autonomic nervous function

目的探讨炎症性肠病患者白细胞介素-6(interleukin-6,IL-6)、细胞黏附分子-1(s ICAM-1)及脂肪细胞因子chemerin水平改变,及其与自主神经功能的相关性。方法分析2015年7月-2016年5月我院收治的46例炎症性肠病患者的临床资料,设为观察组,49例健康人群作为对照组。结果观察组患者血清IL-6、s ICAM-1及脂肪细胞因子chemerin水平明显高于对照组(P<0.05);观察组患者卧立位血压差高于对照组(P<0.05),观察组患者握力试验的血压反应、卧立位心率差水平明显低于对照组(P<0.05);观察组患者血清IL-6、s ICAM-1与卧立位血压差、卧立位心率差均呈正相关,脂肪细胞因子chemerin与自主神经功能改变的无明显相关性。结论炎症性肠病的发病与IL-6、s ICAM-1及chemerin水平升高、交感神经功能增强、迷走神经功能减弱有关,IL-6、s ICAM-1与自主神经功能改变有正相关性。

Objective To investigate the changes of IL-6, sICAM-1 and chemerin in patients with inflammatory bow- el disease and the correlation with autonomic nervous function. Methods The clinical data of 46 patients with inflammatory bowel disease were analyzed from Jul. 2015 to May. 2016 in our hospital, and as the observation group, 49 healthy people were selected as control group. Results In observation group, the serum levels of IL-6, sICAM-1 and chemerin were significantly higher than those in control group （P 〈 0.05 ） ; Orthostatic blood pressure difference in the observation group was higher than that in the control group （P 〈 0.05） , handgrip test blood pressure response and orthostatic heart rate difference in the observation group were significantly lower than those in the control group （P 〈 0.05） ; serum sICAM-1, IL-6 were positively related to orthostatic blood pressure difference and orthostatic heart rate difference, the chemerin was not related to the autonomic nerve function. Conclusion The incidence of IBD is related to the elevation of IL-6, sICAM-1 and chemerin, the enhancement of sympathetic nerve function and the decrease of the vagus nerve function, sICAM-1 and IL-6 are positively related to the change of autonomic nervous function.