参与肝纤维化形成的细胞和细胞因子的新进展

New progress of the cells and cytokines involved in the formation of liver fibrosis

肝纤维化是各种慢性肝病的共同病理过程,许多类型的细胞与细胞因子参与肝纤维化的发生、发展。最近,对参与肝纤维化的细胞和细胞因子分子机制有了新的认识。终止肝纤维化的过程,可能会逆转晚期肝纤维化甚至肝硬化。很多研究已更好地阐述肝纤维化所涉及的细胞和细胞因子分子机制。肝星状细胞的激活是肝纤维化的中心事件,辅以其他基质来源的细胞。确定不同类型细胞的相互作用,揭示细胞因子对这些细胞的调节机制,会发现新的治疗靶点。本文就细胞及细胞因子在肝纤维化发病中的作用机制作一概述。

Liver fibrosis is a common pathological process of various chronic liver diseases. Many types of cells and cytokines are involved in the occurrence and development of liver fibrosis. Recently, a new understanding of the cellular and molecular mechanisms of liver fibrosis occurrs. Data indicate that the termination of fibrogenic processes may allow the reversal of advanced fibrosis and even cirrhosis. A lot of researches can better explain the cellular and molecular mechanisms involved in liver fibrosis. Activation of hepatic stellate cells remains a central event in fibrosis, complemented by other sources of matrix-producing cells. To determine the interaction of different types of cells, to reveal the role of cytokines on these cells and regulatory mechanisms, will find new therapeutic targets. In this paper, the pathogenesis of liver fibrosis from the aspects of cells and cytokines were summarized.