中医综合疗法对慢性肾衰竭患者残留肾功能的影响

Effect of Combination Therapy of TCM on Residual Renal Function in Patients with Chronic Renal Failure

目的:观察中药口服与灌肠综合疗法对慢性肾衰竭患者残留肾功能的保护作用。方法:选取慢性肾衰竭患者70例为研究对象,采用随机数字表法分为观察组和对照组各35例,对照组给予常规西医治疗,观察组在此基础上给予中药口服联合灌肠综合治疗,对比两组治疗有效率及治疗前后中医证候积分,比较内生肌酐清除率(endogenous creatinine clearance rate,Ccr)、血清肌酐(serum creatinine,Scr)、尿素氮(blood urea nitrogen,BUN)含量及治疗前后血浆白蛋白(albumin,ALB)、血红蛋白(hemoglobin,Hb)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)水平,同时观察不良反应。结果:观察组治疗有效率88.57%明显高于对照组65.71%(P<0.05);观察组治疗后中医证候总积分(8.26±0.41)分,对照组中医证候总积分(16.43±0.20)分,两组比较,差异有统计学意义(P<0.05);治疗后观察组Ccr(35.24±1.88)m L·min^(-1)、Hb(98.36±1.22)g·L^(-1)、Scr(281.67±1.56)μmol·L^(-1)、BUN(7.75±0.54)mmol·L^(-1)、ALB(35.17±1.06)g·L^(-1)、Hs-CRP(3.45±1.02)mg·L^(-1),对照组Ccr(30.47±1.34)m L·min-1、Hb(90.35±1.07)g·L^(-1)、Scr(326.45±1.14)μmol·L^(-1)、BUN(10.26±0.17)mmol·L^(-1)、ALB(38.48±0.44)g·L^(-1)、Hs-CRP(5.12±0.55)mg·L^(-1),两组比较,差异有统计学意义(P<0.05);观察组不良反应发生率8.57%,对照组不良反应发生率5.71%,两组比较无显著差异(P>0.05)。结论:中药口服与灌肠综合治疗对慢性肾衰竭患者残留肾功能具有明显保护作用,且安全性高。

Objective：To observe the protective effect of traditional Chinese oral medicine combined with enema therapy on residual renal function in patients with chronic renal failure.Methods：Sixty patients with chronic renal failure were selected as the study subjects and were randomly divided into observation group and control group,with 35 cases in each group.The control group was treated with conventional western medicine.On the basis of this,the patients in the observation group were treated with TCM oral medicine combined with enema.The Creatinine,Ccr）,serum creatinine（Scr）,blood urea nitrogen（BUN）and plasma albumin（ALB）,Hemoglobin（Hb）and hypersensitive C-reactive protein（hs-CRP）of the two groups before and after treatment were measured and the adverse reactions were observed.Results：The effective rate of the observation group was 88.57%and that of the control group was 65.71%.There was significant difference between the both groups（P〈0.05）.The total score of TCM syndromes of the control group was（8.26±0.41）and the total score of TCM syndromes of the control group was（16.43±0.20）.The difference between the two groups was statistically significant（P〈0.05）.After treatment,the expressions of Ccr（35.24±（35.17±1.06）g·L^-1and Hs-CRP（3.45±1.02）mg·L^-1of the control group and the expressions of Ccr（30.47±1.34）mL.Min^-1,Hb（90.35±1.07）g·L^-1,Scr（326.45±1.14）μmol·L^-1,BUN（10.26±0.17）mmol·L^-1,ALB（38.48±0.44）g·L^-1and Hs-CRP（5.12±0.55）mg·L^-1were measured.The differences between the two groups were statistically significant（P〈0.05）.The incidence of adverse reactions in the observation group was 8.57%,and the incidence of adverse reactions in the control group was 5.71%.There was no significant difference between the two groups（P〈0.05）.Conclusion：The comprehensive treatment of TCM oral medicine combined with enema has obvious protective effect on residual renal function in patients with chronic renal failure with high safety.