桂枝甘草龙骨牡蛎汤加减治疗围绝经失眠的临床分析

Clinical Analysis of Modified Guizhi Gancao Longgu Muli Decoction in the Treatment of Perimenopausal Insomnia

目的探讨围绝经失眠经桂枝甘草龙骨牡蛎汤加减治疗的临床疗效。方法从我院2015年10月—2016年10月收治的围绝经失眠患者中选取94例进行研究,并根据其入院顺序随机分为两组,每组47例;对照组采用常规西药治疗,观察组则在此基础上给予桂枝甘草龙骨牡蛎汤加减治疗,比较两组患者的临床治疗效果以及治疗前后的焦虑评分。结果观察组的总有效率为89.36%,高于对照组的61.70%,组间差异显著,存在统计学意义(P<0.05)。治疗后,两组患者的HAMA评分均明显下降,和治疗前比较,差异具有统计学意义,且观察组显著低于对照组,组间差异存在统计学意义(P<0.05)。结论采用桂枝甘草龙骨牡蛎汤加减治疗围绝经失眠可以显著提高治疗效果,改善焦虑等心理状态,促进睡眠,疗效确切,适合进行临床推广。

Objective To investigate the clinical effect of Guizhi Gancao Longgu Muli decoction in the treatment of perimenopausal insomnia.Methods 94 cases of perimenopausal insomnia patients in our hospital from October 2015 to October 2016 were selected,and according to the order of admission,they were randomly divided into two groups,with 47 cases in each group. The control group used conventional Western medicine treatment,and the observation group was given Guizhi Gancao Longgu Muli decoction treatment on the basis of the control group. The clinical therapeutic effects of the two groups and the anxiety scores before and after treatment were compared. Results After comparison,the total effective rate of the observation group was 89. 36% which was higher than 61. 70% of the control group,there was significant difference between the two groups,and the difference was statistically significant（ P 0. 05）. After treatment,HAMA scores of the two groups were significantly decreased,comparing with before treatment,and the difference was statistically significant. HAMA scores of the observation group was significantly lower than that of the control group,and the difference was statistically significant（ P 0. 05）.Conclusion The use of Guizhi Gancao Longgu Muli decoction in the treatment of perimenopausal insomnia can significantly improve the therapeutic effect and the psychological state of anxiety,promote sleep,has definitely curative effect,and is suitable for clinical application.