早期流产与生殖道解脲支原体及人乳头瘤病毒感染的相关性分析

Relationship between first trimester abortion with Ureaplasma urealyticum and HPV infection

目的比较解脲支原体(UU)与人乳头瘤病毒(HPV)感染对早期妊娠妇女的异常影响,探讨生殖道感染与早期妊娠流产的相关性。方法共选取460例孕妇纳入观测对象,其中230例为自发性流产患者(观察组),另外230例正常妊娠并分娩的孕妇作为对照组。采集两组研究对象的宫颈拭子标本,分别用相应PCR反应试剂盒进行UU与不同型HPV检测。结果 460例孕妇的UU总感染率为17.83%(82/460),其中观察组为24.8%(57/230),对照组仅为10.9%(25/230),两组差异有统计学意义(P<0.01)。HPV总感染率为20.2%(93/460),其中观察组为29.1%(67/230),对照组仅为11.3%(26/230),差异也有统计学意义(P<0.01)。其中单一亚型HPV感染比例为14.1%(65/460),多亚型混合感染比例为6.1%(28/460),而高危型感染率为18.3%(84/460),低危型感染率为8.91%(41/460)。HPV合并UU感染率为2.6%(12/460),其中观察组11例,对照组1例,差异有统计学意义(P<0.01)。结论早期妊娠女性生殖道UU及HPV感染可能导致自发性流产,但其具体机制及不同型别HPV的作用尚需进一步进行研究。

Objective To compare the abnormal influence of Ureaplasma urealyticum（UU ） and human papillomavirus（HPV） infection on early pregnant women,and to investigate the correlation between reproductive tract infection with spontaneous abortion in early pregnant women. Methods A total of 460 pregnant women were included in the observation subjects, including 230 cases of spontaneous abortion （observation group） and other 230 normal pregnant women of delivery as the control group. The cervical swab samples were collected from the research subjects of the two groups and performed the UU and different types of HPV detections by using corresponding PCR reaction reagents. Results The UU total infection rate among 460 pregnant women was 17. 83%（82/ 460） , which of the observation group was 24. 8%（57/230） and which the control group was only 10. 9%（25/230）, the difference between the two groups was statistically significant（P 〈0. 01）. The HPV total infection rate was 20. 2 % （93/460） , which of the observation group was 29. l %（67/230） and which of the control group was only 11. 3 % （26/230） , the difference was statistically significant. Among them,the single subtype HPV infection proportion was 14. 1 % （65/460） , the multiple subtype HPV mixed infection proportion was 6. 1 % （28/460） , while the high risk type HPV infection rate was 18. 3 % （84/460） and the low risk type HPV infection rate was 8. 91%（41/460）. The infection rate of UU combined HPV was 2. 6%（12/460） , in which the observation had 11 case and control group had 1 case,the difference was statistically significant （P 〈0. 01）. Conclusion Infection of UU and HPV in early pregnant women may lead to spontaneous abortion. But its concrete mechanism and the role of different types of HPV need to be further studied.