缺氧环境下LPS诱导人牙周膜成纤维细胞炎性损伤的研究进展

Research progress of inflammatory injury in human periodontal ligament cells induced by LPS under hypoxia

内毒素(Lipopolysaccharide,LPS)是牙周炎炎症免疫反应中重要的毒力因子之一,直接或间接地作用于牙周膜成纤维细胞导致其炎性损伤。而牙周膜成纤维细胞因其所处位置的特殊性,长期处于相对缺氧的环境中。所以通过体外模拟牙周膜成纤维细胞发生炎性损伤时的体内环境,有利于阐明缺氧条件下细胞炎性损伤机制。本文就缺氧环境下LPS诱导的人牙周膜成纤维细胞炎性损伤的研究做一系统性回顾。

Lipopolysaccharide （LPS） ,which is one of the main virulence factors of periodontitis, results in the inflammatory injury of human periodontal ligament cells （hPDLCs） directly or indirectly. However, hPDLCs reside in a inflamed and hypoxic microenviron- ment due to their special location. Thus, simulating the inflammatory microenvironment of hPDLCs in vivo will be beneficial to clarifying the mechanism of periodontitis. In this paper, research on the inflammatory injury in hPDLCs induced by LPS under hypoxia will be en- tensively reviewed.