2011—2015年保定市健康人群脊髓灰质炎抗体水平检测分析

Analysis on polio antibody levels surveillance of healthy population in Baoding from 2011 to 2015

目的了解保定市健康人群脊髓灰质炎(脊灰)中和抗体水平,评价近几年的接种效果,为相关部门及时制订免疫策略提供一定的科学依据。方法从保定市23个县、区(市)中每年抽取1个县、区(市)的健康人群,应用微量中和实验法检测脊灰抗体水平。结果在检测的健康人群血清标本中,脊灰Ⅰ型、Ⅱ型和Ⅲ型抗体的阳性率分别为99.83%、99.83%和100.00%,抗体几何平均滴度(geometric mean titer,GMT)分别为1∶15795,1∶15434和1∶14978。Ⅰ、Ⅱ、Ⅲ型脊灰抗体不同年龄组GMT和不同县、区(市)间Ⅰ、Ⅱ、Ⅲ型抗体阳性率比较差异均无统计学意义。结论保定市计划免疫冷链系统运转状况良好,脊灰疫苗免疫效果显著,已形成对脊灰病毒有效的免疫屏障。

Objective To understand the poliomyelitis antibody level of healthy population in Baoding city from 2011 to 2015 and evaluate immune effect, so as to provide scientific basis for the control and prevention. Methods The poliomyelitis antibody level of healthy people was detected by neutralization test of the micro cells from each country of Baoding city （ contain 23 counties）. Results The neutralizing antibody positive rates of Ⅰ , Ⅱ , Ⅲ viruses were 99.83%, 99.83% and 100%, respectively, and the geometric mean titer （GMT） were 1 ： 157.95, 1 ： 154. 34, 1 ： 149.78. There were no statistical differences for Ⅰ , Ⅱ , and Ⅲ polio antibody GMT between different age groups and different counties or districts. Conclusion The immunization cold-chain system of Baoding city is being run in good condition and effect of polio vaccine immunization is remarkable. Importantly, a protective barrier had been built against polio in healthy people in Baoding city.