胎膜早破孕妇阴道病原菌感染与耐药性探讨

Discussion on infections and drug resistance of genital tract pathogenic bacteria in pregnant women with premature rupture of membrane

目的通过对胎膜早破孕妇患者阴道病原菌感染以及耐药性分析,为临床上合理性用药以及控制感染提供理论依据。方法回顾性分析5 138例胎膜早破孕妇患者的所有临床资料,进行常规性菌群与支原体培养以及衣原体的分析。结果 5 138例胎膜早破孕妇患者中检出阳性1 734例(易感率为33.7%);病原学阳性结果支原体培养为1 283例(占25.0%),衣原体测定为143例(占2.8%),细菌为941株(占18.3%),常见病原菌主要是革兰阴性菌329株(占35.0%),以大肠埃希菌为主;革兰阳性菌358株(占38.0%),以β-溶血性链球菌、肠球菌、溶血性葡萄球菌等为主;真菌254株(占27.0%),以白色念珠菌为主。常见的支原体、病原菌耐药性均较高。结论因胎膜早破孕妇患者常见的病原菌耐药性均较高,临床应依据药敏试验结果合理性用药。

Objective To analyze the infections and drug resistance of genital tract pathogens in pregnant women patients with premature rupture of membranes（PROM） , so as to provide theoretic guidance for rational clinical drug use and infections control. Methods Reviewed and analyzed all the clinical data in 5 138 cases of pregnant women patients with premature rupture of membranes（PROM）. Undertook regular bacteria and mycoplasma culture and analysis of ehlamydia. Results Among 5 138 pregnant women with premature rupture of membranes, 1 734 women（ susceptibility rate of 33.7% ） were tested; the number of pathogen positive mycoplasma was l 283 （ accounting for 25.0% ） ; 143 patients were diagnosed with chlamydia（ accounting for 2.8% ） ; 941 strains were bacteria（ accounting for 18.3% ）. The common pathogen were 329 strains of gram - negative bacteria （accounting for 35.0% ）, mainly presented in Escherichia coli; gram -positive bacteria was detected in 358 strains（ accounting for 38.0% ）, mainly presented in β - Streptococcus, Enterococcus, Staphylococcus aureus ; Fungi was detected in 254 strains （accounting for 27.0% ）, mainly presented in Candida albicaus ; the common mycoplasma and pathogens had high drug resistance. Conclusion Due to the high drug resistance of common pathogens in pregnant women patients with premature rupture of membranes（ PROM）, rational clinical drug use should be based on drug sensitive test results.