雌激素受体β与酪氨酸激酶受体B在子宫内膜异位症相关卵巢癌中的表达及意义

Expression and significance of estrogen receptor-β and tyrosine kinase receptor-B in endometriosis associated ovarian cancer

恶变的卵巢子宫内膜异位症称为子宫内膜异位症相关卵巢癌（EAOC），其发病机制尚不明确，但许多研究发现了其恶变的高危因素。最近的研究为雌激素受体β（ER—β）可以影响卵巢癌细胞的增殖、运动和凋亡提供证据。酪氨酸激酶受体B（TrkB）脑源性生长因子（BDNF）信号途径与子宫内膜异位症的发病有直接关系，其抗失巢凋亡作用是癌细胞转移的先决条件。在神经系统中，雌二醇与雌激素受体结合可通过多种途径促进TrkB／BDNF的高表达并增强其活性。因此，在EAOC中，恶变的高危因素与ER—β表达的相关性，ER-β与TrkB／BDNF信号途径的关系亟待我们的探索。

Malignant transformation of ovarian endometriosis is known as endometriosis associated ovarian cancer （EAOC）. However, the carcinogenic pathways by which EAOC develops remained poorly understood, and numerous studies found the risk factors of malignant transformation. Recent studies have provided evidence that estrogen receptor-β （ER-β） can influence the proliferation, motility and apoptosis of ovarian cancer cells. The signal pathway of tyrosine kinase receptor-B （TrkB）/ brain-derived neurotrophic factor （BDNF） has a direct relation with the endometriosis, and its anti-anoikis plays a prerequisite role in proliferation of cancer. In the nervous system, estradiol and estrogen receptor can be combined through a variety of ways to promote BDNF/TrkB high expression and activity enhancement. Therefore, the relationship between high-risk factors of malignant transformation and ER-β expression and ER-β and TrkB/BDNF signal pathways need to be explored in EAOC.