局部使用曲安奈德对促进肉芽肿性小叶性乳腺炎术后伤口愈合的临床研究

Clinical study of local application of triamcinolone acetonide in promoting wound healing after granulomatous lobular mastitis operation

目的 探讨曲安奈德局部使用对肉芽肿性小叶性乳腺炎（GLM）术后伤口愈合及复发的影响.方法 回顾性分析55例病灶直径〉5 cm的GLM患者的临床资料,均行乳腺脓肿切开引流联合炎性病灶清除术.术后常规换药31例（对照组）,常规换药过程中加用曲安奈德24例（试验组）.比较两组患者的换药时间、治愈率、复发率,观察试验组激素相关不良反应.结果 试验组换药时间明显短于对照组[（58±19）d比（71±25）d],差异有统计学意义（P〈0.05）;试验组和对照组治愈率和复发率比较差异无统计学意义[91.7%（22/24）比83.9%（26/31）和9.1%（2/22）比15.4%（4/26）,P〉0.05].试验组患者未出现明显的激素相关不良反应.结论 曲安奈德局部使用可促进GLM术后患者伤口愈合,可能有助于进一步提高治愈率及减少复发率.

Objective To investigate the effect of local application of triamcinolone acetonide in promoting wound healing and recurrence after granulomatous lobular mastitis （GLM） operation. Methods The clinical data of 55 GLM patients with the diameter 〉 5 cm were retrospectively analyzed, and all patients treated with incision drainage to breast abscess and removal of inflammatory lesions. Thirty - one patients were treated with routine dressing change after operation （control group）, and 24 patients were treated with routine dressing change and triamcinolone acetonide injection after operation （experiment group）. The wound dressing time, recovery rate and recurrence rate were compared between 2 groups, and hormone related adverse reaction of experiment group was observed. Results The wound dressing time in experiment group was significantly shorter than that in control group：（58 ± 19） d vs. （71 ±25） d, and there was statistical difference （P〈0.05）. There were no statistical differences in the recovery rate and recurrence rate between experiment group and control group：91.7%（22/24） vs. 83.9%（26/31） and 9.1%（2/22） vs. 15.4% （4/26）, P〉0.05. The patients of experiment group did not have the hormone related adverse reaction. Conclusions The local application of triamcinolone acetonide after GLM operation can accelerate the wound healing, and it may also contribute to higher recovery rate and lower recurrence rate.