养胃配方颗粒组方对慢性萎缩性胃炎患者血清炎症指标及中医症状积分影响

Effect of Yangwei Granule Prescription on Chronic Atrophic Gastritis Serum Inflammation Indexes and TCM Symptom Score

目的:探讨养胃配方颗粒组方对慢性萎缩性胃炎患者血清炎症指标及中医症状积分的影响。方法:选取2014年5月—2015年6月在我院住院部及门诊就诊被诊断为慢性萎缩性胃炎的患者90例,采用随机数字表法分为对照组和实验组,实验组应用院内协定处方养胃配方颗粒组方,对照组给予维酶素片,两组治疗3个疗程。结果:治疗前,实验组及对照组IL-32、CRP水平比较无明显差异,治疗后,实验组IL-32、CRP分别为(40.34±10.65)pg/m L、(8.35±4.31)mg/L,较对照组(52.25±9.21)pg/m L(21.56±3.27)mg/L水平低,差异有统计学意义,、P<0.05;治疗前,两组证候积分无明显差异,治疗后,两组中医证候均有所下降,其中身倦乏力、便溏腹泻两组之间无明显差异,实验组胃脘隐痛、反酸烧心、食后脘闷、纳呆少食、恶心呕吐及中医证候总积分均较对照组低,差异有统计学意义,P<0.05;实验组总有效率为84.44%,对照组总有效率为73.33%,差异有统计学意义,P<0.05。结论:养胃配方颗粒组方可以改善慢性萎缩性胃炎患者中医证候,降低血清IL-32及CRP水平。

Objective： To investigation the effect of Yangwei Granule prescription on chronic atrophic gastritis serum inflammation indexes and TCM symptom score. Methods ： 90 cases of patients diagnosed as chronic atrophy gastritis were selected in May 2014 to June 2015 in our hospital hospitalization department and outpatient, were randomly divided into experimental group and control group, the experimental group used in hospital agreement prescription Yangwei Granule prescription, the control group were treated with Weimeisu Tablets. Results： Before treatment, the experimental group and the control group, the IL-32 level of CRP had no significant difference, after treatment, the experimental group IL-32 and CRP were （ 40.34 ± 10.65 ）pg/mL, （ 8.35 ± 4.31 ）mg/L, compared with the control group （ 52.25 ± 9.21 ）pg/mL, （21.56 ± 3.27 ）mg/L level is low, the difference was significant meaning, P〈0.05; before treatment, no significant difference between the two groups, symptom scores after treatment, two groups of TCM syndromes were decreased, the body tired fatigue, loose stools, diarrhea no significant difference between the two groups, the experimental group of epigastric pain, heartburn, abdominal nausea after eating, loss of appetite, nausea and vomiting and the TCM syndrome total score was lower than the control group, the difference was statistically significant, P〈0.05 ; the total efficiency of the experimental group was 84.44%, control group total effective rate was 73.33%, the difference was statistically significant, P〈0.05. Conclusion： Yangwei Granule prescription can improve patients with chronic atrophic gastritis of TCM syndrome, reduce serum IL-32 and CRP levels.