摘要
目的:探讨竹沥颗粒和鲜竹沥口服液对慢性支气管炎(Chronic bronchitis,CB)模型大鼠肺组织中超氧化物歧化酶(superoxide dismutase,SOD)活性、丙二醛(malondiadehyde,MDA)水平和羟脯氨酸(hydroxyproline,HP)水平的影响。方法:将40只SD大鼠随机分为对照组(10只)、模型组(10只)、鲜竹沥组(10只)和竹沥颗粒组(10只)。将模型组大鼠、鲜竹沥组大鼠和竹沥颗粒组大鼠制成CB模型。使用浓度为0.7%的氯化钠溶液对模型组大鼠进行灌胃,使用鲜竹沥口服液对鲜竹沥组大鼠进行灌胃,使用竹沥颗粒对竹沥颗粒组大鼠进行灌胃,并对比四组大鼠肺组织中SOD的活性、MDA的水平和HP的水平。结果:与对照组大鼠相比,模型组大鼠肺组织中SOD的活性更低,其肺组织中MDA的水平和HP的水平更高,差异有统计学意义(P<0.05)。与模型组大鼠相比,鲜竹沥组大鼠和竹沥颗粒组大鼠肺组织中SOD的活性更高,其肺组织中MDA的水平和HP的水平更低,差异有统计学意义(P<0.05)。鲜竹沥组大鼠和竹沥颗粒组大鼠肺组织中SOD的活性、MDA的水平和HP的水平相比差异无统计学意义(P>0.05)。结论:使用竹沥颗粒和鲜竹沥口服液对CB模型大鼠进行灌胃,可有效地提高其肺组织中SOD的活性,降低其肺组织中MDA的水平和HP的水平。
Objective： To study effect of Zhuli Granule and Xianzhuli Decoction on SOD（superoxide dismutase） activity, MDA（malondiadehyde ）level and HP（hydroxyproline） level in rats lung tissue model of CB（Chronic bronchitis）. Methods 40 rats were randomly divided into 4 groups： control group, chronic bronchitis （CB） group, Xianzhuli group and Zhuli group. Make model group, Zhuli group and Xianzhuli group into CB model. Model group were given normal saline（concentration is 0.7%） by gavage, Xianzhuli group were given Xianzhuli decoction by gavage, Zhuli group were given Zhuli granule by garage ,compare SOD activity, MDA level and HP level of 4 groups rats. Results Compare with control group, SOD activity of model group was lower, MDA level and HP level were higher, discrepancy of research results were statistically significant （P 〈 0.05）. Compare with model group,SOD activity of Xianzhuli group and Zhuli group were higher, MDA level and HP level, discrepancy of research results were statistically significant （P 〈 0.05）. Discrepancy of SOD activity, MDA level and HP level of Xianzhuli group and Zhuli group were no statistically significant （P 〉 0.05）. Conclusion Give Zhuli granule or Xianzhuli decoction by garage to rats model of CB can improve SOD activity and decrease MDA level and HP level in lung tissue.
