2型糖尿病肾病患者血清同型半胱氨酸胱抑素C及D-二聚体检测的临床价值

The clinical value of serum homocysteine, cystatin C and D-di- mer detection in patients with type 2 diabetic mellitus ne- phropathy

目的探讨2型糖尿病肾病患者血清同型半胱氨酸、胱抑素C及D-二聚体榆测的临眯价值。方法将30例2型糖尿病患者设为A组，30例糖尿病肾病患者设为B组，30名健康志愿者设为C组，采集3组晨空腹12h静脉血3m15m1，检测血清同型半胱氨酸、胱抑素C及D-二聚体水平，并进行对比分析。结果A组与B组血清同型半胱氨酸、胱抑素C及D二聚体水平均显著高于C组，B组显著高于A组，差异均有极显著性（P〈0.01）。结论检测2型糖尿病肾病患者血清同型半胱氨酸、胱抑素C及D-二聚体水平，有利于早期预防、诊断和治疗。

Objective To explore the clinical value of serum homocysteine, cystatin C and D-dimer detec tion in patients with type 2 diabetics mellitus （T2DM） nephropathy. Methods Thirty T2DM patients were assigned to group A, 30 diabetic nephropathy ones to B, 30 healthy volunteers to C, morning fasting venous blood of 3 groups collected, serum homocysteine, cystatin C and D-dimer levels detected, and cont rastive analyses conducted. Results Serum homocysteine, cystatin C and D-dimer levels were significantly higher in group A and B than in C, so were those in B than in A, and differences were very significant （P〈0.01）. Conclusion Serum homocysteine, cystatin C and D-dimer detection in patients with T2DM nephropathy is beneficial to early prevention, diagnosis and treatment.