男性酒依赖患者性腺激素水平实验室检测及其意义

Laboratory detection of gonadal hormone levels of male alcohol dependence pa- tients and significance

目的了解住院男性酒依赖患者性腺激素水平的变化，为临床诊断与治疗提供依据。方法对58例男性酒依赖患者（酒依赖组）及58名正常健康人（对照组）采用电化学发光法测定血清垂体泌乳素、睾丸酮、孕酮、促卵泡激素、促黄体生成素、雌二醇激素水平，对两组检测结果进行对比分析。结果酒依赖组血清垂体泌乳素、促卵泡激素、促黄体生成素、雌二醇水平显著高于对照组（P〈0.05或0．01），孕酮水平显著低于对照组（P〈0.01），睾丸酮水平与对照组比较差异无显著性（P〉0．05）。酒依赖组患者性腺激素血清垂体泌乳素、促卵泡激素、促黄体生成素、雌二醇水平与年龄呈正相关关系，但无统计学意义（P〉0.05）；孕酮水平与年龄呈负相关关系，但元统计学意义（P〉0．05）；睾丸酮水平与年龄呈正相关关系，差异有统计学意义（P〈0．05）。结论男性酒依赖患者性腺激素水平异常，性腺轴存在功能失调，临床应加强酒依赖患者性腺激素的检测与治疗。

Objective To survey the changes of gonadal hormone levels of male alcohol dependence （AD） patients to provide basis for clinical diagnosis and treatment. Methods Fifty-eight male AD patients were assigned to dependence group and 58 normal healthy people to control group, serum pituitary prolactin （PRL）, testosterone （T） , progesterone （PROG）, follicle stimulating hormone （FSH）, luteinizing hormone （LH） and estradiol （E2） levels detected using electrochemiluminescence, and detection results of 2 groups contrastively analyzed. Results Serum PRL, FSH, LH and E2 levels were significantly higher （P〈0.05 or 0.01） and RROG lower （P^0.01） in dependency than in control group, group difference in T wasn＇t significant （P〉0.05）. Serum PRL, FSH, LH and E2 levels were positively related to ages in dependence group, but which had no statistical significance （P〈0.05） ; PROG level was negatively related to ages, but which had no statistical significance （P〈0.05） ; T level was positively related to ages, which had statistical significance （P〈0.05）. Conclusion Gonad hormone levels of male AD patients are abnormal, gonad axis functions imbalance, and the detection of gonadal hormone and treatment should be clinically enhanced.